Gene interactions and pathways from curated databases and text-mining

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NFKB1 — PCNA

Text-mined interactions from Literome

Engelhardt et al., Antioxid Redox Signal 1999 (Lung Diseases...) : Two such examples have utilized dominant inhibitory forms of the retinoblastoma gene product ( Rb ) and IkappaBalpha which prevent activation of cyclin dependent protein kinases and NF-kappaB , respectively
Guo et al., Mol Cell Biol 2003 (Adenocarcinoma...) : Inhibiting NF-kappa B transcriptional activity in MCF+FIR cells, by using mutant I kappa B alpha, inhibited radioresistance as well as reducing steady-state levels of MnSOD, 14-3-3 zeta, GADD153, cyclin A, and cyclin B1 mRNA
Ogasawara et al., J Bone Miner Res 2004 : Osteoclast differentiation by RANKL requires NF-kappaB mediated downregulation of cyclin dependent kinase 6 (Cdk6)
Moreno-GarcĂ­a et al., J Immunol 2005 : Loss of PKC activity blocked CD38 dependent, B cell proliferation, NF-kappaB activation , and subsequent expression of cyclin-D2
Liang et al., J Neurosci Res 2007 : To evaluate whether nuclear factor-kappaB (NF-kappaB) activation promotes cell cycle entry and neuronal apoptosis, we studied the relation among NF-kappaB mediated cyclin induction, bromodeoxyuridine ( BrdU ) incorporation, and apoptosis initiation in rat striatal neurons following excitotoxic insult
Sandur et al., Carcinogenesis 2007 : The suppression of NF-kappaB activity correlated with inhibition of NF-kappaB reporter activity and with down-regulation of cyclooxygenase-2, cyclin D1 and vascular endothelial growth factor, all regulated by NF-kappaB
Lee et al., J Biomed Sci 2008 (Colitis...) : In addition, consumption of UDN glycoprotein attenuated the activities of proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), and inhibited the DNA binding activities of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in the mice colonic tissue
Lee et al., American journal of physiology. Renal physiology 2008 : Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR, p44/42 MAPKs, or NF-kappaB blocked the BSA induced increases in cyclin D1, cyclin dependent kinase (CDK)4 , cyclin E, or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression
Wang et al., Int J Cancer 2010 (Cell Transformation, Neoplastic...) : This was associated with significantly lower proliferating cell nuclear antigen positive hepatocytes and cyclinD1 protein, as well as decreased activation of extracellular signal regulated kinase and nuclear NF-kappaB
Scheper et al., PloS one 2010 : Several pathways that control cell survival under stress, namely RNF8 dependent DNA damage recognition and repair, PCNA dependent DNA damage tolerance and activation of NF-kappaB by extrinsic signals, are regulated by the tagging of key proteins with lysine 63-based polyubiquitylated chains, catalyzed by the conserved ubiquitin conjugating heterodimeric enzyme Ubc13-Uev