◀ Back to NFKB1
NFKB1 — PCNA
Text-mined interactions from Literome
Engelhardt et al., Antioxid Redox Signal 1999
(Lung Diseases...) :
Two such examples have utilized dominant inhibitory forms of the retinoblastoma gene product ( Rb ) and IkappaBalpha which prevent activation of
cyclin dependent protein kinases and
NF-kappaB , respectively
Guo et al., Mol Cell Biol 2003
(Adenocarcinoma...) :
Inhibiting
NF-kappa B transcriptional activity in MCF+FIR cells, by using mutant I kappa B alpha,
inhibited radioresistance as well as reducing steady-state levels of MnSOD, 14-3-3 zeta, GADD153,
cyclin A, and cyclin B1 mRNA
Ogasawara et al., J Bone Miner Res 2004
:
Osteoclast differentiation by RANKL requires
NF-kappaB mediated downregulation of
cyclin dependent kinase 6 (Cdk6)
Moreno-GarcĂa et al., J Immunol 2005
:
Loss of PKC activity blocked CD38 dependent, B cell proliferation,
NF-kappaB activation , and subsequent expression of
cyclin-D2
Liang et al., J Neurosci Res 2007
:
To evaluate whether nuclear factor-kappaB (NF-kappaB) activation promotes cell cycle entry and neuronal apoptosis, we studied the relation among
NF-kappaB mediated
cyclin induction, bromodeoxyuridine ( BrdU ) incorporation, and apoptosis initiation in rat striatal neurons following excitotoxic insult
Sandur et al., Carcinogenesis 2007
:
The suppression of NF-kappaB activity correlated with inhibition of NF-kappaB reporter activity and with down-regulation of cyclooxygenase-2,
cyclin D1 and vascular endothelial growth factor, all
regulated by
NF-kappaB
Lee et al., J Biomed Sci 2008
(Colitis...) :
In addition, consumption of UDN glycoprotein attenuated the activities of
proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), and
inhibited the DNA binding activities of
nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in the mice colonic tissue
Lee et al., American journal of physiology. Renal physiology 2008
:
Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR, p44/42 MAPKs, or
NF-kappaB blocked the BSA induced increases in cyclin D1,
cyclin dependent kinase (CDK)4 , cyclin E, or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression
Wang et al., Int J Cancer 2010
(Cell Transformation, Neoplastic...) :
This was associated with significantly lower
proliferating cell nuclear antigen positive hepatocytes and cyclinD1 protein, as well as decreased
activation of extracellular signal regulated kinase and nuclear
NF-kappaB
Scheper et al., PloS one 2010
:
Several pathways that control cell survival under stress, namely RNF8 dependent DNA damage recognition and repair,
PCNA dependent DNA damage tolerance and activation of
NF-kappaB by extrinsic signals, are regulated by the tagging of key proteins with lysine 63-based polyubiquitylated chains, catalyzed by the conserved ubiquitin conjugating heterodimeric enzyme Ubc13-Uev