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GCG — PDX1

Text-mined interactions from Literome

Stoffers et al., Diabetes 2000 (Diabetes Mellitus) : Here, we show that the insulinotropic hormone glucagon-like peptide (GLP)-1 , which is produced by the intestine, enhances the pancreatic expression of the homeodomain transcription factor IDX-1 that is critical for pancreas development and the transcriptional regulation of the insulin gene
Ritz-Laser et al., Diabetologia 2003 : Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription ... We investigated the inhibitory role of Pdx1 on glucagon gene expression in vitro ... To understand the mechanism by which Pdx1 inhibits glucagon gene expression, we studied its effect on glucagon promoter activity in non-islet cells using transient transfections and gel-shift analysis ... Since Pdx1 interacts directly with Pax-6 and Cdx-2/3 forming heterodimers, we suggest that Pdx1 inhibits glucagon gene transcription through protein to protein interactions with Pax-6 and Cdx-2/3
Linning et al., Pancreas 2004 : Overexpression of Pdx-1 in HPC cultures stimulated somatostatin, glucagon , and carbonic anhydrase expression but had no effect on insulin gene expression
Schisler et al., Proc Natl Acad Sci U S A 2005 : RNA interference ( RNAi ) -mediated suppression of Nkx6.1 in class 3 cells resulted in a doubling of glucagon mRNA, with no effect on Pdx1 levels, whereas suppression of Pdx1 in class 3 cells caused a 12-fold increase in glucagon transcript levels, demonstrating independent effects of Nkx6.1 and Pdx1 on glucagon expression in beta cell lines
Holland et al., Diabetes 2005 (Diabetes Mellitus, Experimental) : Repression of Pdx1 in adult mice impaired expression of insulin and glucagon , leading to diabetes within 14 days