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PEBP1 — RAF1

Pathways - manually collected, often from reviews:

• NCI Pathway Database ErbB1 downstream signaling: RKIP/RAF1 complex (PEBP1-RAF1) → RAF1 (RAF1) (modification, collaborate) Corbit et al., Mol Cell Biol 2000*, Corbit et al., J Biol Chem 2003*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: RKIP/RAF1 complex (PEBP1-RAF1) → RKIP (PEBP1) (modification, collaborate) Corbit et al., Mol Cell Biol 2000*, Corbit et al., J Biol Chem 2003*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: RKIP/RAF1 complex (PEBP1-RAF1) → PKC zeta (PRKCZ) (modification, collaborate) Corbit et al., Mol Cell Biol 2000*, Corbit et al., J Biol Chem 2003*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: RAF1 (RAF1) → RKIP (PEBP1) (modification, collaborate) Corbit et al., Mol Cell Biol 2000*, Corbit et al., J Biol Chem 2003*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: RAF1 — PEBP1 Lorenz et al., Nature 2003*
• IRef Bind_translation Interaction: RAF1 — PEBP1 (coimmunoprecipitation) Lorenz et al., Nature 2003*
• IRef Biogrid Interaction: RAF1 — PEBP1 (physical association, affinity chromatography technology) Lorenz et al., Nature 2003*
• IRef Biogrid Interaction: RAF1 — PEBP1 (direct interaction, pull down) Yeung et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: RAF1 — PEBP1 (physical association, affinity chromatography technology) Yeung et al., Mol Cell Biol 2000*
• IRef Dip Interaction: Complex of ALOX15-RAF1-PEBP1 (anti bait coimmunoprecipitation) Zhao et al., Proc Natl Acad Sci U S A 2011*
• IRef Dip Interaction: RAF1 — PEBP1 (physical association, anti bait coimmunoprecipitation) Zhao et al., Proc Natl Acad Sci U S A 2011*
• IRef Hprd Interaction: Complex of RAF1-MAPK1-PEBP1-RAF1-MAPK1-PEBP1-MAPK1-PEBP1-RAF1 (in vivo) Park et al., FEBS Lett 2006*
• IRef Hprd Interaction: RAF1 — PEBP1 (in vitro) Park et al., FEBS Lett 2006*
• IRef Intact Interaction: RAF1 — PEBP1 (direct interaction, surface plasmon resonance) Park et al., FEBS Lett 2006*
• IRef Intact Interaction: RAF1 — PEBP1 (physical association, peptide array) Park et al., FEBS Lett 2006*
• IRef Intact Interaction: RAF1 — PEBP1 (physical association, pull down) Park et al., FEBS Lett 2006*
• IRef Intact Interaction: RAF1 — PEBP1 (physical association, anti bait coimmunoprecipitation) Park et al., FEBS Lett 2006*
• IRef Intact Interaction: RAF1 — PEBP1 (physical association, anti tag coimmunoprecipitation) Park et al., FEBS Lett 2006*
• IRef Ophid Interaction: RAF1 — PEBP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: RAF1 — PEBP1 (aggregation, confirmational text mining) Maki et al., J Neuropathol Exp Neurol 2002*

Text-mined interactions from Literome

Klysik et al., Cell Signal 2008 (Alzheimer Disease...) : In its non phosphorylated form RKIP-1 negatively regulates the Raf/MEK/ERK pathway by interfering with the activity of Raf-1
Garcia et al., EMBO Rep 2009 (MAP Kinase Signaling System) : Consistent with the properties of a scaffold, PEBP4 enhances the RAF1-MEK interaction and the activation of MEK at low expression levels, whereas it inhibits these parameters at higher expression levels
Takemura et al., J Biol Chem 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Raf kinase inhibitor protein (RKIP) inhibits activation of MEK by Raf-1 and its downstream signal transduction, resulting in blocking the MAP kinase pathway
Deiss et al., J Biol Chem 2012 : Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein coupled receptor kinase ( GRK ) 2