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IL1B — PGF
Text-mined interactions from Literome
Noguchi et al., J Periodontal Res 2001
(Periodontal Diseases) :
IL-6 mRNA was expressed in PGF2alpha stimulated HGF, and
PGF2alpha increased IL-6 mRNA levels
induced by
IL-1beta and TNFalpha
Noguchi et al., J Periodontal Res 2001
:
Northern blot analysis revealed that PGF2alpha enhanced MMP-1 mRNA expression in HGF and that
PGF2alpha increased MMP-1 mRNA levels
induced by
IL-1beta
Sato et al., Eur J Obstet Gynecol Reprod Biol 2002
:
IL-1beta and TNF-alpha both
stimulated production of PGE ( 2 ) and
6-keto-PGF ( 1alpha ) in a concentration dependent manner
Estevez et al., Prostaglandins Leukot Essent Fatty Acids 2002
:
Moreover,
IL-1beta effects on
PGF2alpha and P4 levels were impaired when a NOS inhibitor N ( W ) -nitro- L -arginine methyl ester ( L-NAME, 600 microM ) was added to the incubation media ... These data demonstrate that : ( i ) at the tested doses ( 1-20 ng/ml ), IL-1beta is involved in CL function through the diminution of P4 production of whole ovarian dispersate culture ; ( ii ) at the highest doses assayed ( 20 ng/ml )
IL-1beta increased
PGF2alpha production ; ( iii ) at these doses, IL-1beta decreased P4 production by means of a cyclooxygenase pathway and ( iv ) the NO system would be a key intermediary second messenger in the IL-1beta actions
Walch et al., Endocrinology 2003
:
IL-1beta increases PGE ( 2 ) and
PGF ( 2alpha ) production ... Pharmacological characterization of receptors involved in PGE ( 2 ) and
PGF ( 2alpha )
regulation of
IL-1beta mRNA levels was ascertained using real-time PCR analyses ... A selective FP agonist, cloprostenol ( 0.1 micro M ), and
PGF ( 2alpha ) ( 10 micro M )
had similar effects on
IL-1beta mRNA levels in progenitors treated with IL-1beta + INDO
Estevez et al., Reproduction 2003
:
In rats, PGF ( 2alpha ) and
interleukin 1beta (IL-1beta) are
involved in structural luteolysis, PGF ( 2alpha ) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing
PGF ( 2alpha ) concentrations
Mitchell et al., J Clin Endocrinol Metab 2005
:
IL-1beta and TNFalpha
caused concentration dependent increases in
9alpha,11beta-PGF ( 2 ) production in human amnion and choriodecidual explants
Ishikawa et al., Endocrinology 2006
:
IL-1beta regulated PGE ( 2 ) and
PGF ( 2alpha ) production and cytokine expression require activation of cyclooxygenase-2 (COX-2) and c-Jun NH ( 2 ) -terminal kinase, as shown using specific enzyme inhibition ... Together, the data indicate an autocrine amplifying loop involving
IL-1beta regulated Sertoli function mediated by COX-2 induced PGE ( 2 ) and
PGF ( 2alpha ) production
Chang et al., J Endod 2009
(MAP Kinase Signaling System...) :
We found that
IL-1beta stimulated
PGF ( 2alpha ) production of human dental pulp cells ... Aspirin inhibited
IL-1beta induced
PGF ( 2alpha ), but not IL-8 production
Tocher et al., Comp Biochem Physiol B Biochem Mol Biol 1996
:
Interleukin-1 beta significantly
stimulated the production of
PGF only
Young et al., Biol Reprod 1997
:
In contrast,
IL-1 beta significantly
stimulated PGF2 alpha production in a dose dependent manner during the mid and late luteal phases ( p < 0.05 ) ... Human CG alone had no effect on PGE2 or PGF2 alpha production by dispersed luteal cells in vitro but inhibited
IL-1 beta stimulated
PGF2 alpha production
Del Vecchio et al., Reprod Fertil Dev 1997
:
Interleukin-1beta stimulated
PGF2alpha in luteal and luteal plus accessory cells, and tended to elevate PGF2alpha in accessory cells ... Indomethacin inhibited the
interleukin-1beta stimulated
PGF2alpha and PGE2 release
Zou et al., Biochem J 1998
:
The presence of superoxide dismutase ( SOD, 100 units/ml ) or the NOS synthase inhibitor Nomega-monomethyl-l-arginine ( 100 microM ) as well as cycloheximide ( 10 microM ) plus actinomycin ( 10 microM ) abolished
IL-1beta mediated down-regulation of
6-oxo-PGF1alpha from PGH2
Longo et al., Mediators Inflamm 1998
:
IL-1beta and LPS
increased both PGE2 and
6-keto-PGF1alpha in a dose dependent fashion with enhanced production detected two hours following exposure
Longo et al., Prostaglandins Other Lipid Mediat 1998
:
VSA, in a dose dependent manner, significantly decreased
IL-1 beta stimulated PGE2 and
PGF2 alpha production