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MAPK6 — PI3

Text-mined interactions from Literome

Perkinton et al., J Neurosci 1999 : Similarly, kainate activated MAPK in a PI 3-kinase dependent manner ... Our results indicate that Ca ( 2+ ) -permeable AMPA receptors transduce signals from the cell surface to the nucleus of neurons through a PI 3-kinase dependent activation of MAPK
Sotsios et al., J Immunol 1999 : Finally, SDF-1 stimulated extracellular signal related kinase ( ERK)-1/2 mitogen activated protein kinase activation was inhibited by PI 3-kinase inhibitors
Versteeg et al., FEBS Lett 2000 : Phosphatidylinositide-3-OH-kinase ( PI 3-kinase ) is an upstream activator of p42/p44 mitogen activated protein kinase ( MAPK ), but the role of PI 3-kinase dependent MAPK remains obscure ... We concluded that basal, but not induced MAPK activity is mediated by PI 3-kinase and that this PI 3-kinase mediated MEK/MAPK activity is essential for cell survival in quiescent cells
Wen et al., J Cell Biochem 2000 : On the other hand, rottlerin ( the selective PKCdelta inhibitor ), SB 203580 ( the selective p38 MAPK inhibitor ), and wortmannin ( the PI 3-kinase inhibitor ) can affect neither cPLA(2) nor ERK phosphorylation
Chun et al., Biochem Biophys Res Commun 2000 : In addition, expression of a constitutively active form of PI3-kinase ( p110* ) enhanced myotube formation and p38 MAPK activation, while expression of a dominant negative form of PI3-kinase ( Deltap85 ) attenuated these responses ... Taken together, we concluded that PI3-kinase activates p38 MAPK , which in turn stimulates muscle differentiation, but that p38 MAPK does not substitute for PI3-kinase in this process
Abounader et al., J Neurochem 2001 (Glioblastoma) : These results support a model of c-met induction by SF/HGF in human glioma cells that uniformly involves Ras, MAPK , and AP-1 and additionally involves PI3-kinase and PKC in some cell lines
Shimada et al., Biol Reprod 2001 : PI 3-kinase exists in cumulus cells and oocytes, and the PI 3-kinase inhibitor, LY294002, suppressed the activation of mitogen activated protein ( MAP ) kinase in denuded oocytes during the beginning of the treatment
Lin et al., Neuron 2001 (MAP Kinase Signaling System) : Tetanus and forskolin induced activation of mitogen activated protein kinase ( MAPK ) was blocked by PI-3 kinase inhibitors, which also inhibited cAMP response element binding protein ( CREB ) phosphorylation
Altmann et al., Biochem Biophys Res Commun 2002 : Inhibitor studies revealed that phosphatidylinositol 3-kinase (PI 3-K) is involved in BA-induced MAPK activation, whereas a minor role was apparent for protein kinase C. MAPK activation by 3-O-acetyl-11-beta-keto-BA was partially inhibited when Ca ( 2+ ) was removed by chelation
Yamamori et al., Biochem Biophys Res Commun 2002 : Phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002, blocked not only p38 MAPK activation but also Rac activation
Trümper et al., J Endocrinol 2002 (MAP Kinase Signaling System) : These interactions included : ( i ) a central role of tyrosine phosphorylation for stimulation of PKA/CREB, MAPK and PI3-kinase/PKB, ( ii ) inhibition of PKA/CREB by the MAPK pathway at the level of MAPK kinase-1 or downstream, ( iii ) activation of MAPK signaling by PI3-kinase and PKA at the level of extracellular-signal regulated kinase 1/2 or upstream, and ( iv ) activation of PKB by MAPK and PKA signaling at the level of PKB or upstream
Grill et al., Blood 2002 (MAP Kinase Signaling System) : Inhibition of increases in PI-3K activity by Ly294002 had no effect on the IL-3 induced activation of p38 MAPK
Kubo et al., Brain Res Mol Brain Res 2002 : Abeta1-40 suppressed the PI-3K dependent Akt phosphorylation but not the mitogen activated protein kinase phosphorylation
Wu et al., J Biol Chem 2003 : SB203580, a p38 MAPK inhibitor, and PD98059, an ERK inhibitor, but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells
Owens et al., J Cell Sci 2003 (Cell Transformation, Neoplastic...) : Responsiveness to TGFbeta could be restored by inhibiting cadherin mediated cell-cell adhesion or phosphoinositide 3-kinase (PI3-K) activity, but not by inhibiting mitogen activated protein kinase ( MAPK ) activity
Fegley et al., J Surg Res 2003 : Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha ( i ) - and pi3-kinase dependent p38 ( MAPK ) activation
Lee et al., Am J Physiol Lung Cell Mol Physiol 2004 : These results suggest that in HTSMCs, LTA stimulated p42/p44 MAPK phosphorylation is mediated through a TLR2 receptor and involves tyrosine kinase, PLC, PKC, Ca ( 2+ ), MEK, and PI 3-kinase
Choudhury et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Ly294002 or a dominant negative PI 3-kinase significantly blocked IFN-gamma induced MAPK activity
Tsai et al., Chem Res Toxicol 2004 (MAP Kinase Signaling System) : This benzo [ a ] pyrene induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [ extracellular signal regulated kinase ( ERK ) /mitogen activated protein kinase ( MAPK ) inhibitor ], and LY294002 [ phosphatidylinositol 3-kinase (PI3K) inhibitor ] but not alpha-naphthoflavone ( aryl hydrocarbon receptor antagonist ) and SB203580 ( p38 MAPK inhibitor )
Vongs et al., Regul Pept 2004 : p42/p44 MAPK activation is blocked by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 but not by the protein kinase A (PKA) inhibitor Rp-cAMPS, indicating that that signal activating the p42/p44 MAPK pathway is conveyed through inositol triphosphate
Couty et al., Biol Cell 2004 (Disease Models, Animal...) : In in vitro systems, HHV-8-GPCR signals via multiple transduction pathways including, activation of phospholipase C and PKC, inhibition of adenylyl cyclase, activation of nuclear factor-kappaB ; activation PI 3-kinase , p42/44 MAPK and Akt/PKB, and activation of JNK/SAPK, p38 MAPK and RAFTK
Mahimainathan et al., American journal of physiology. Renal physiology 2005 : Because EGF activates PI3-kinase, which also regulates DNA synthesis, the effect of PI3-kinase on MAPK activity was also examined ... Inhibition of PI3-kinase signaling blocked EGF induced MAPK activity as well as Elk-1 dependent reporter transcription and c-fos gene transcription ... These data provide the evidence that a linear signal transduction pathway involving PI3-kinase dependent MAPK regulates EGF induced DNA synthesis in mesangial cells by regulating c-fos and p27 ( Kip1 ) expression
Grandage et al., Leukemia 2005 (Acute Disease...) : In 10 of 18 samples, PI3-kinase contributes to MAPK activation as incubation with LY294002 leads to a marked reduction in its phosphorylation
Gibbs et al., Int Arch Allergy Immunol 2005 : The IgE dependent release of these mediators in basophils crucially involves PI 3-kinase and the subsequent activation of p38 MAPK and ERK1 & 2
Bando et al., Exp Eye Res 2006 (MAP Kinase Signaling System...) : We performed the gel contraction assay to evaluate the effect of PDGF in cultured ARPE-19 cells under the presence or absence of PD98059, MAPK inhibitor or wortmannin, PI3K inhibitor
Mookerjee Basu et al., Antimicrob Agents Chemother 2006 : Herein, we show that SAG induces extracellular signal regulated kinase 1 ( ERK-1 ) and ERK-2 phosphorylation through phosphoinositide 3-kinase (PI3K) , protein kinase C, and Ras activation and p38 mitogen activated protein kinase ( MAPK ) phosphorylation through PI3K and Akt activation
Ignatov et al., Br J Pharmacol 2006 : RANTES enhanced the phosphorylation of AKT and mitogen activated protein kinase ( MAPK ) in GPR75 transfected cells and this effect was blocked by the PLC inhibitor U73122 and the phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin
Nakatani et al., Biochem Biophys Res Commun 2007 : Treatment of 3Y1 cells with AVP resulted in transient activation of p44/42 mitogen activated protein kinase ( MAPK ) and cPLA(2)alpha, and phosphatidylinositol 3-kinase (PI3K) inhibitor blocked not only AVP induced PGE ( 2 ) synthesis but also MAPK activation, suggesting that PI3K is involved in the AVP induced MAPK and cPLA(2)alpha activation, which initiates the production of PGE ( 2 )
LaMarca et al., Hum Reprod 2008 : EGF induced the phosphorylation of the phosphatidylinositol 3-kinase (PI3-K) dependent proteins, Akt and GSK-3beta as well as both p42/44 MAPK and p38 mitogen activated protein kinases ( MAPK )
Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : Leptin induction of cytokines/receptors generally involved JAK2 and MAPK activation, but PI-3K phosphorylation was required for leptin increase of LIF, IL-1/IL-1R tI
Cazarolli et al., Chem Biol Interact 2009 (Diabetes Mellitus, Experimental...) : The effect of compound 1 on glucose uptake was completely nullified by wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3K) , RO318220, an inhibitor of protein kinase C ( PKC ), PD98059, a specific inhibitor of mitogen activated protein kinase ( MEK ) , cycloheximide, an inhibitor of protein synthesis, and colchicine, a microtubule depolymerizing agent
Wang et al., Cardiovasc Res 2010 (Atherosclerosis) : OxLDL induced the activation of p38 mitogen activating protein kinase ( MAPK ) through phosphatidylinositol 3-kinase (PI3K)
Descorbeth et al., J Mol Cell Cardiol 2010 : Furthermore, high glucose induced enhanced levels of Gqalpha, G11alpha and PLCbeta were also attenuated by PD98059, an inhibitor of mitogen activated protein kinase ( MAPK ) and wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3-K)
Grotegut et al., Int J Oncol 2010 (Hepatoblastoma...) : Here, we demonstrate that HGF has no impact on overall cell viability and proliferation of HB cells, although signal transduction occurs downstream of HGF, such as c-Met phosphorylation, activation of phosphoinositide 3-kinase (PI3K)/AKT and mitogen activated protein kinase ( MAPK ) /ERK-1/2 signaling
Nishiura et al., Apoptosis 2010 : This alternative p38MAPK activation could be pharmacologically suppressed not only by the downregulation of phosphoinositide 3-kinase (PI3K) by LY294002, but also by the over-activation of protein kinase C by phorbol 12-myristate 13-acetate
Kim et al., Immune network 2011 : Furthermore, PI3-K activity was required for the HBHA induced activation of ERK1/2 and p38 MAPK , but not JNK, pathways
Cheng et al., Br J Pharmacol 2012 (Hypotension) : Effects of a selective antagonist of Y ( 1 ) receptors, a PKC inhibitor, a PI3 kinase inhibitor, a NOS inhibitor, an endothelial NOS (eNOS)-selective inhibitor, a neuronal NOS (nNOS)-specific inhibitor or a MAPK inhibitor , on responses to microinjection of NPY into the NTS of Wistar-Kyoto rats were studied to determine the underlying mechanisms
Cazarolli et al., Fitoterapia 2012 (Hyperglycemia) : The presence of specific insulin signaling inhibitors, such as wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K) , RO318220, an inhibitor of protein kinase C ( PKC ), PD98059, an inhibitor of mitogen activated protein kinase ( MEK ) , and HNMPA ( AM ) 3, an insulin receptor tyrosine kinase activity inhibitor showed that apigenin-6-C-ß-fucopyranoside triggers different metabolic pathways in skeletal muscle
Liu et al., Exp Cell Res 2013 (Acute Kidney Injury) : The BMSC migration could also be partly blocked by LY294002 ( phosphoinositide 3-kinase (PI3K) inhibitor ) and PD98059 ( MAPK inhibitor )
Chang et al., J Biol Chem 1995 : We conclude that ( i ) transgenic expression of kinase-defective insulin receptors exerts dominant negative effects at the level of receptor auto-phosphorylation and kinase activation ; ( ii ) insulin receptor tyrosine kinase activity is required for in vivo insulin stimulated IRS-1 phosphorylation, IRS-1 associated PI 3-kinase activation , phosphorylation of mitogen activated protein kinase , and c-fos gene induction in skeletal muscle ; ( iii ) hybrid receptor formation is likely to contribute to the in vivo dominant negative effects of kinase-defective receptor expression
Kole et al., J Biol Chem 1996 : Furthermore, treatment of CHO/HIRc cells with this N-stearyl peptide led to a significant enhancement of the insulin induced association of phosphatidylinositol (PI) 3-kinase activity with insulin receptor substrate 1 and the activation of mitogen activated protein kinase
Kobayashi et al., J Biol Chem 1997 : Induction of active PI 3-kinase resulted in activation of Jun N-terminal kinase but not of mitogen activated protein kinase or protein kinase B/Rac protein kinase/Akt
Lin et al., J Biol Chem 1997 : The role of PI 3-kinase in regulating heat shock activation of MAPK and p70 S6K was investigated using wortmannin, a specific pharmacological inhibitor of PI 3-kinase
Choudhury et al., Am J Physiol 1997 : Because Ras is an upstream regulator of the kinase cascade leading to the activation of mitogen activated protein kinase ( MAPK ), we determined whether activation of PI-3-kinase is necessary for activation of MAPK
Schuppin et al., Diabetes 1998 (Insulinoma...) : This serum stimulated DNA synthesis was prevented by inhibitors of tyrosine protein kinase and phosphatidylinositol (PI) 3-kinase activities, as well as the activation of mitogen activated protein ( MAP ) kinase and p70S6K
Agati et al., J Biol Chem 1998 : Thus, insulin inhibition of PKA induced PEPCK expression does not require MAPK activation but does require activation of PI3-kinase , although this signal is not transmitted through the PKB or PKC pathways
Bondeva et al., Science 1998 : Phosphoinositide 3-kinases (PI3Ks) activate protein kinase PKB ( also termed Akt ), and PI3Kgamma activated by heterotrimeric guanosine triphosphate binding protein can stimulate mitogen activated protein kinase ( MAPK ) ... Moreover, stimulation of MAPK in response to lysophosphatidic acid was blocked by catalytically inactive PI3Kgamma but not by hybrid PI3Kgammas