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PIK3CA — PLCG2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Bobe et al., Blood 2001
(Agammaglobulinemia) :
Phosphatidylinositol 3-kinase dependent translocation of
phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation
Yamamori et al., Biochem Biophys Res Commun 2004
:
Furthermore,
PI3K inhibitors
reduced the activation of
phospholipase Cgamma2 without affecting tyrosine phosphorylation on it
Dai et al., Mol Cell Biol 2006
:
Interestingly, PLCgamma2 deficiency had no effect on BCR mediated PI3K activation, whereas
PI3K deficiency only partially
blocked activation of
PLCgamma2
Gilio et al., J Biol Chem 2009
(Thrombosis) :
The targeting of platelet PI3Kalpha or -beta strongly and selectively suppressed GPVI induced Ca ( 2+ ) mobilization and inositol 1,4,5-triphosphate production, thus demonstrating
enhancement of
phospholipase Cgamma2 by
PI3Kalpha/beta