◀ Back to PIK3R1
PIK3CB — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database LPA receptor mediated events:
RHOA/GTP complex (RHOA)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, activates)
Baudhuin et al., Mol Pharmacol 2002*
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
Gab1 (GAB1)
→
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
Gab1 (GAB1)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
EGFR (EGFR)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR (EGFR)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
LPA/LPA1-2-3 complex (LPAR1_LPAR2_LPAR3)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, activates)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
G beta/gamma complex (GNB1-GNG2)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, activates)
Maier et al., J Biol Chem 1999*, Van Leeuwen et al., J Biol Chem 2003, Hawes et al., J Biol Chem 1996*, Kurosu et al., J Biol Chem 1997*, Roche et al., Mol Cell Biol 1998*
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
None
(modification, activates)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
(modification, activates)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
PKC epsilon (PRKCE)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, activates)
Fleming et al., J Biol Chem 1997*
Evidence: mutant phenotype, assay
-
Reactome Reaction:
PIK3CB
→
PIK3R1
(reaction)
Odai et al., J Biol Chem 1995, Feshchenko et al., J Biol Chem 1998
-
Reactome Reaction:
PIK3CB
→
PIK3R1
(direct_complex)
-
WikiPathways AMP-activated Protein Kinase (AMPK) Signaling:
INS-IGF2
→
Complex of PIK3R3-PIK3R1-PIK3CB-PIK3CA-PIK3CG-PIK3CD-PIK3R2
(activation)
-
WikiPathways PI3K-AKT-mTOR signaling pathway and therapeutic opportunities:
HRAS/NRAS/KRAS
→
Complex of PIK3CA-PIK3CB-PIK3R1-PIK3R2-PIK3R3-PIK3CG
(activation)
-
WikiPathways Signaling Pathways in Glioblastoma:
GAB1
→
Complex of PIK3R1-PIK3R2-PIK3CA-PIK3CB-PIK3CD
(mim-stimulation)
-
WikiPathways Signaling Pathways in Glioblastoma:
SRC
→
Complex of PIK3R1-PIK3R2-PIK3CA-PIK3CB-PIK3CD
(mim-stimulation)
-
WikiPathways Signaling Pathways in Glioblastoma:
IRS1
→
Complex of PIK3R1-PIK3R2-PIK3CA-PIK3CB-PIK3CD
(mim-stimulation)
-
WikiPathways AMP-activated Protein Kinase (AMPK) Signaling:
Complex of PIK3R3-PIK3R1-PIK3CB-PIK3CA-PIK3CG-PIK3CD-PIK3R2
→
AKT1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PIK3CB
—
PIK3R1
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
IRef Biogrid Interaction:
PIK3CB
—
PIK3R1
(physical association, affinity chromatography technology)
Hu et al., Mol Cell Biol 1994*
-
IRef Dip Interaction:
PIK3CB
—
PIK3R1
(physical association, anti tag coimmunoprecipitation)
Sun et al., Proc Natl Acad Sci U S A 2010*
-
IRef Hprd Interaction:
PIK3CB
—
PIK3R1
(in vivo)
Katada et al., Chem Phys Lipids 1999*, Hu et al., Mol Cell Biol 1994*
-
IRef Hprd Interaction:
PIK3CB
—
PIK3R1
(in vitro)
Katada et al., Chem Phys Lipids 1999*, Hu et al., Mol Cell Biol 1994*
-
IRef Innatedb Interaction:
PIK3CB
—
PIK3R1
(unknown, -)
Foukas et al., Mol Cell Biol 2004*
-
IRef Intact Interaction:
Complex of 81 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 43 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 18 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 20 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 111 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 29 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 40 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 12 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Ophid Interaction:
PIK3CB
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
PIK3CB
—
PIK3R1
(aggregation, confirmational text mining)
Hu et al., Mol Cell Biol 1994*
Text-mined interactions from Literome
Komori et al., Clinical calcium 2006
:
Phosphoinositide 3-kinase
(PI3K)-Akt signaling enhances DNA binding of Runx2 and Runx2 dependent transcription, and Runx2
upregulates PI3K subunits ( p85 and
p110 beta ) and Akt
Ciraolo et al., Science signaling 2008
(Cell Transformation, Neoplastic...) :
Pharmacological and genetic analyses of p110beta function revealed that
p110beta catalytic activity is
required for
PI3K signaling downstream of heterotrimeric guanine nucleotide binding protein ( G protein ) -coupled receptors as well as to sustain long-term insulin signaling
Billottet et al., Cancer Res 2009
(Leukemia, Promyelocytic, Acute) :
In summary, class I
PI3K signaling,
mediated by
p110beta and p110delta, plays an important role in basal and ATRA induced cell survival mechanisms in APL
Jiang et al., J Biol Chem 2010
(Prostatic Neoplasms) :
Basal
PI3K activity was
mediated by p110beta in PC3 cells and by both
p110beta and p110delta in LNCaP cells, whereas p110alpha was required for PI3K activation in response to RTK stimulation by heregulin-beta1 ... These findings show that basal
PI3K activity in PTEN-deficient PCa cells is RTK independent and can be
mediated by
p110beta and p110delta ... Increased
p110beta expression in PCa may be
required for RTK independent
PI3K pathway activation in adult prostate epithelium with genetic or epigenetic PTEN down-regulation