Gene interactions and pathways from curated databases and text-mining

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PIK3CB — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Komori et al., Clinical calcium 2006 : Phosphoinositide 3-kinase (PI3K)-Akt signaling enhances DNA binding of Runx2 and Runx2 dependent transcription, and Runx2 upregulates PI3K subunits ( p85 and p110 beta ) and Akt
Ciraolo et al., Science signaling 2008 (Cell Transformation, Neoplastic...) : Pharmacological and genetic analyses of p110beta function revealed that p110beta catalytic activity is required for PI3K signaling downstream of heterotrimeric guanine nucleotide binding protein ( G protein ) -coupled receptors as well as to sustain long-term insulin signaling
Billottet et al., Cancer Res 2009 (Leukemia, Promyelocytic, Acute) : In summary, class I PI3K signaling, mediated by p110beta and p110delta, plays an important role in basal and ATRA induced cell survival mechanisms in APL
Jiang et al., J Biol Chem 2010 (Prostatic Neoplasms) : Basal PI3K activity was mediated by p110beta in PC3 cells and by both p110beta and p110delta in LNCaP cells, whereas p110alpha was required for PI3K activation in response to RTK stimulation by heregulin-beta1 ... These findings show that basal PI3K activity in PTEN-deficient PCa cells is RTK independent and can be mediated by p110beta and p110delta ... Increased p110beta expression in PCa may be required for RTK independent PI3K pathway activation in adult prostate epithelium with genetic or epigenetic PTEN down-regulation