Gene interactions and pathways from curated databases and text-mining

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CTGF — PIK3R1

Text-mined interactions from Literome

Wu et al., Kidney Int 2006 : P-PI3-K blockade downregulated the CTGF stimulated expression of P-PI3-K , P-Akt, and NF-kappaB but not P-p42/44 MAPK, and partially decreased the release of the above chemokines ... LXA ( 4 ) dose-dependently inhibited the CTGF stimulated mRNA expression and protein release of the above chemokines, and the expression of P-p42/44MAPK, P-PI3-K , P-Akt, and NF-kappaB
Wu et al., Growth Factors 2008 : PI3-K blockade downregulated the CTGF stimulated expressions of phosphorylated PI3-K , PKB and NF-kappaB but not phosphorylated ERK1/2, partially decreased the expressions of the above chemokines
Xiao et al., Cell Physiol Biochem 2011 : Specific inhibitors of PI3K suppressed stretch -induced CTGF expression in a time dependent manner
Kim et al., Mol Cell Biochem 2012 (Burns...) : In the presence of inhibitors of PI3K , Src, Smad, or reactive oxygen species, the effect of NRG1 on CTGF expression decreased significantly
Zhen et al., PloS one 2013 : Mechanistic analysis revealed that CTGF suppression activated FAK/PI3K/AKT and its downstream signals regulating the cell cycle, epithelial-mesenchymal transition (EMT) and MMPs