Gene interactions and pathways from curated databases and text-mining

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AKT3 — PIKFYVE

Text-mined interactions from Literome

Ikonomov et al., Exp Cell Res 2007 : Loss of PIKfyve-ArPIKfyve reduced insulin stimulated Akt phosphorylation and the cell surface accumulation of GLUT4 or IRAP, but not GLUT1 containing vesicles without affecting overall expression of these proteins
Pakladok et al., Cell Physiol Biochem 2013 : SGK's and PKB/Akt's activate phosphatidylinositol-3-phosphate-5-kinase PIKfyve , which in turn up-regulates several carriers and channels ... Conclusion : hERG is up-regulated by PIKfyve , which is in turn activated by PKB/Akt
Er et al., Science signaling 2013 : Upon EGF stimulation, AKT phosphorylated and activated the kinase PIKfyve [ FYVE containing phosphatidylinositol 3-phosphate 5-kinase ], which promoted vesicle trafficking to lysosomes ... Similar regulation occurred with platelet derived growth factor receptor ( PDGFR ), suggesting that AKT phosphorylation and activation of PIKfyve is likely to be a common feedback mechanism for terminating RTK signaling and reducing receptor abundance