Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — PIP

Text-mined interactions from Literome

Xie et al., Mol Biol Cell 2005 : These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn activated PI3K
Etkovitz et al., Biol Reprod 2007 : On the other hand, activation of PKC by phorbol myristate acetate enhanced PIP ( 2 ( 4,5 ) ) and F-actin formation mediated by PI4K activity, while the PI3K activity and intracellular PIP ( 3 ( 3,4,5 ) ) levels were reduced
Yamamoto et al., Biomed Res 2008 (Ion Channel Gating) : These results suggest that the activation of VRAC current requires the presence of intracellular PIP3, that PI3K mediated increase in PIP3 level is sufficient to fully activate VRAC current, and that PIP3 alone without osmotic stimulation can not induce VRAC current
Bandara et al., PLoS Comput Biol 2009 : The experimental approach included the activation of endogenous phosphoinositide 3-kinase (PI3K) by chemically induced recruitment of a regulatory peptide, reversible inhibition of PI3K using a kinase inhibitor, and monitoring of the PI3K mediated production of PIP ( 3 ) lipids using the pleckstrin homology (PH) domain of Akt