Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — PLA2G4A

Text-mined interactions from Literome

Silfani et al., Arch Biochem Biophys 2002 : However, it is not known whether PI3K is involved in the Ang II-induced activation of cPLA(2) or if this mechanism is associated with the Ang II-mediated growth of VSMC ... Therefore, we used cultured rat VSMC to examine the role of PI3K in the Ang II-dependent phosphorylation of cPLA(2) , release of AA, and growth induced by Ang II
Nakatani et al., Biochem Biophys Res Commun 2007 : Treatment of 3Y1 cells with AVP resulted in transient activation of p44/42 mitogen activated protein kinase ( MAPK ) and cPLA(2)alpha, and phosphatidylinositol 3-kinase (PI3K) inhibitor blocked not only AVP induced PGE ( 2 ) synthesis but also MAPK activation, suggesting that PI3K is involved in the AVP induced MAPK and cPLA(2)alpha activation, which initiates the production of PGE ( 2 )
Isenovic et al., Cell Biol Int 2009 : Therefore, this investigation used primary cultured rat VSMCs to examine the role of PI3K and ERK1/2 in the INS dependent phosphorylation of cPLA2 and proliferation induced by INS ... Thus, we hypothesized that INS stimulates VSMCs proliferation via a mechanism involving the PI3K dependent activation of cPLA2 and release of arachidonic acid ( AA ), which activates ERK1/2 and further amplifies cPLA2 activity