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PIK3R1 — PLA2G4A
Text-mined interactions from Literome
Silfani et al., Arch Biochem Biophys 2002
:
However, it is not known whether
PI3K is
involved in the Ang II-induced activation of
cPLA(2) or if this mechanism is associated with the Ang II-mediated growth of VSMC ... Therefore, we used cultured rat VSMC to examine the
role of
PI3K in the Ang II-dependent phosphorylation of
cPLA(2) , release of AA, and growth induced by Ang II
Nakatani et al., Biochem Biophys Res Commun 2007
:
Treatment of 3Y1 cells with AVP resulted in transient activation of p44/42 mitogen activated protein kinase ( MAPK ) and cPLA(2)alpha, and phosphatidylinositol 3-kinase (PI3K) inhibitor blocked not only AVP induced PGE ( 2 ) synthesis but also MAPK activation, suggesting that
PI3K is
involved in the AVP induced MAPK and
cPLA(2)alpha activation, which initiates the production of PGE ( 2 )
Isenovic et al., Cell Biol Int 2009
:
Therefore, this investigation used primary cultured rat VSMCs to examine the
role of
PI3K and ERK1/2 in the INS dependent phosphorylation of
cPLA2 and proliferation induced by INS ... Thus, we hypothesized that INS stimulates VSMCs proliferation via a mechanism involving the
PI3K dependent activation of
cPLA2 and release of arachidonic acid ( AA ), which activates ERK1/2 and further amplifies cPLA2 activity