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PIK3R1 — PLAT
Text-mined interactions from Literome
Lee et al., J Neurochem 2007
:
Consistent with neurotrophic effects,
tPA activated Raf-K/ERK, PKC and
PI3-K/Akt , 5-60 min after treatment
Cho et al., Life Sci 2013
:
Glucose deprivation induced activation of
PI3K-Akt-GSK3ß , p38 and AMPK, and inhibition of these pathways using LY294002, SB203580 and compound C significantly
inhibited glucose deprivation induced
tPA down-regulation, demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes