Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — PLAT

Text-mined interactions from Literome

Lee et al., J Neurochem 2007 : Consistent with neurotrophic effects, tPA activated Raf-K/ERK, PKC and PI3-K/Akt , 5-60 min after treatment
Cho et al., Life Sci 2013 : Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and AMPK, and inhibition of these pathways using LY294002, SB203580 and compound C significantly inhibited glucose deprivation induced tPA down-regulation, demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes