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PIK3R1 — PLAU
Text-mined interactions from Literome
Kusch et al., J Biol Chem 2000
:
We demonstrate that
uPA induces
PI3-K activation, which is abolished in VSMC expressing the dominant negative form of Tyk2 ... The regulatory subunit p85 of PI3-K co-immunoprecipitates with Tyk2 but not with Jak1, Jak2, or Jak3, and
uPA stimulation
increases the
PI3-K activity in Tyk2 immunoprecipitates ... We provide evidence that the Tyk2 mediated
PI3-K activation in
response to
uPA is required for VSMC migration
Chandrasekar et al., Oncogene 2003
(Central Nervous System Neoplasms...) :
Downregulation of
uPA inhibits migration and
PI3k/Akt signaling in glioblastoma cells
Sliva et al., Curr Cancer Drug Targets 2004
(Neoplasm Invasiveness...) :
The inhibition of PKC and
PI3K signaling ( through NF-kappaB and AP-1 )
suppressed the secretion of
uPA , resulting in the inhibition of motility of highly invasive breast cancer cells
Nicholl et al., J Vasc Surg 2005
:
uPA activation of
PI3K and MKK3/6 was EGFR dependent and that of MEK1 was EGFR independent
Poettler et al., Thromb Haemost 2012
:
Thus, VEGF165, VEGF-E, FGF-2, EGF as well as HGF induced a
PI3k dependent activation of
pro-uPA when bound to uPAR, which led to an increase in cell surface fibrinolytic activity