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FGF4 — PLCG1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
FGF4
→
PLCG1
(reaction)
Carpenter et al., Exp Cell Res 1999, Cross et al., J Cell Sci 2000, Hart et al., Oncogene 2000, Chen et al., Oncogene 2005, Hatch et al., J Biol Chem 2006, Cha et al., Mol Cancer Res 2008, Gartside et al., Mol Cancer Res 2009, di Martino et al., Oncogene 2009
-
Reactome Reaction:
FGF4
→
PLCG1
(indirect_complex)
Carpenter et al., Exp Cell Res 1999, Cross et al., J Cell Sci 2000, Hart et al., Oncogene 2000, Chen et al., Oncogene 2005, Hatch et al., J Biol Chem 2006, Cha et al., Mol Cancer Res 2008, Gartside et al., Mol Cancer Res 2009, di Martino et al., Oncogene 2009
Text-mined interactions from Literome
Sa et al., Mol Cell Biochem 1999
:
Upon binding to FGFR1, basic
FGF stimulates cytosolic form of phospholipase A2 ( cPLA2 ),
phospholipase C-gamma1 ( PLC-gamma1 ) and phospholipase D ( PLD ), the key enzymes for the production of various lipid second messengers, in a tyrosine kinase dependent manner ... Upon binding to FGFR1, basic
FGF stimulates cytosolic form of phospholipase A2 ( cPLA2 ),
phospholipase C-gamma1 ( PLC-gamma1 ) and phospholipase D ( PLD ), the key enzymes for the production of various lipid second messengers, in a tyrosine kinase dependent manner
Koyama et al., Dev Growth Differ 2008
:
However,
FGF7 and FGF10
stimulated phosphorylation of both
PLCgamma1 and PI3K, but elicited only minimal phosphorylation of ERK-1/2