UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

CD79A — PLCG2

Pathways - manually collected, often from reviews:

NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
Adachi et al., J Biol Chem 2001
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → CD72/SHP1 complex (CD72-PTPN6) (modification, collaborate)
Adachi et al., J Biol Chem 2001
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → SHP1 (PTPN6) (modification, collaborate) Adachi et al., J Biol Chem 2001
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → CD72/SHP1 complex (CD72-PTPN6) (modification, collaborate)
Adachi et al., J Biol Chem 2001
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → SHP1 (PTPN6) (modification, collaborate) Adachi et al., J Biol Chem 2001
NCI Pathway Database BCR signaling pathway: SAB (SH3BP5) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, inhibits)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → PLCgamma2 (PLCG2) (modification, collaborate) Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → Btk (BTK) (modification, collaborate) Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
NCI Pathway Database BCR signaling pathway: PLCgamma2 (PLCG2) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → CD72 (CD72) (modification, collaborate) Fusaki et al., Eur J Immunol 2000
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
Fusaki et al., Eur J Immunol 2000
NCI Pathway Database BCR signaling pathway: CD72 (CD72) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
Fusaki et al., Eur J Immunol 2000
NCI Pathway Database BCR signaling pathway: SHIP (INPP5D) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, inhibits)
NCI Pathway Database BCR signaling pathway: None → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, activates)
NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → None (modification, activates)
Reactome Reaction: CD79A → PLCG2 (indirect_complex) Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998

Text-mined interactions from Literome

Watanabe et al., J Biol Chem 2001 : Substitution of all four tyrosine residues almost completely eliminated the BCR induced PLCgamma2 phosphorylation, indicating that these residues include the major phosphorylation sites upon BCR engagement
Benschop et al., J Immunol 2001 : BCR induced tyrosine phosphorylation of CD79a, Lyn, B cell linker protein, and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag
Wen et al., J Biol Chem 2003 : PLCgamma2 plays a critical role in B cell receptor (BCR) signaling and its targeted deletion results in defective B cell development and function
Bai et al., Mol Cell Biol 2007 : Phospholipase Cgamma2 ( PLCgamma2 ) is critical for pre-B-cell receptor ( pre-BCR ) and BCR signaling
Venkataraman et al., Mol Immunol 1998 : Previous studies have shown that PKA-activation blocks BCR induced phospholipase Cgamma-activation and calcium mobilization