Gene interactions and pathways from curated databases and text-mining

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MMP25 — PLG

Text-mined interactions from Literome

Ramos-DeSimone et al., J Biol Chem 1999 (Neoplasm Invasiveness) : When the MMP-9/TIMP ratio exceeds 1.0, MMP-9 activation progresses, but through an interacting protease cascade involving plasmin and stromelysin 1 ( MMP-3 )
Balcerzak et al., J Anim Sci 2001 : The MMP are regulated at the levels of transcription, zymogen activation by plasmin or membrane-type- ( MT ) MMP, and control of enzyme activity by tissue inhibitors of metalloproteinases ( TIMP )
Hosomi et al., Stroke 2001 (Acute Disease...) : Plasminogen activators (PAs) may also play a role in ECM degradation by the generation of plasmin or by MMP activation
Monea et al., J Cell Physiol 2002 : Thus, plasmin can activate proMMP-2 only in the presence of MT1-MMP ; however, this process does not require the catalytic activity of MT1-MMP
May et al., Thromb Haemost 2005 (Arteriosclerosis) : We studied the effect of E-LDL on the activation of plasminogen and matrix metalloproteinases ( MMPs ) in monocytes and vascular smooth muscle cells ( VSMCs ) as well as on MMP activation during cellular interactions
Stempien-Otero et al., J Biol Chem 2006 (Fibrosis) : We did not detect plasmin mediated activation of TGF-beta1, MMP-2 , or MMP-9 in hearts of SR-uPA+/o mice
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010 : Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM accumulation in part through suppression of plasmin generation and matrix metalloproteinase ( MMP ) activation
Ghosh et al., J Cell Physiol 2012 (Fibrosis) : During wound healing, elevated levels of PAI-1 inhibit uPA/tPA/plasmin and plasmin dependent MMP activities, and, thus, help expedite wound healing