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IFNG — PLP1

Text-mined interactions from Literome

Pelfrey et al., J Neuroimmunol 2002 (Disease Progression...) : With respect to PLP induced IFNgamma secretion, both MS and control females responded higher than their corresponding males
Fredrikson et al., Neurology 1992 (Multiple Sclerosis) : Evaluation of T-cell repertoire by enumeration of cells secreting interferon-gamma in response to proteolipid protein (PLP) , myelin basic protein (MBP), and to various synthetic MBP peptides revealed similar patterns of T-cell reactivity within the families both in MS-affected parents and unaffected children
Sun et al., Eur J Immunol 1991 (Encephalomyelitis, Autoimmune, Experimental...) : To identify a possible role of PLP as target antigen in MS, we evaluated T cell immunity to PLP in blood and cerebrospinal fluid (CSF) from patients with MS and controls by counting cells which in response to PLP in short-term cultures secreted interferon-gamma
Lyons et al., J Autoimmun 2008 (Encephalomyelitis, Autoimmune, Experimental) : However, during chronic disease lymphoid cells isolated from B cell-/- mice proliferated to a greater extent and produced more interferon-gamma in response to the overlapping peptide PLP185-206 and to the smaller internal peptide PLP185-199 than did WT mice
Link et al., J Neuroimmunol 1994 (Multiple Sclerosis...) : There were elevated levels of cells that in response to MBP and PLP expressed IFN-gamma , IL-4 and TGF-beta mRNA in blood and further enriched in CSF in both ON and MS, compared to patients with other neurological diseases
Link et al., Ann Neurol 1994 (Multiple Sclerosis...) : There are mononuclear cells in blood and cerebrospinal fluid of patients with MS that produce interferon-gamma and interleukin-4 in response to myelin basic protein (MBP) and proteolipid protein (PLP)
Link et al., Neurology 1994 (Multiple Sclerosis...) : High numbers of IFN-gamma and IL-4 mRNA expressing cells in response to MBP and PLP were detected in patients with untreated MS, and to AChR in MG ... The levels of IFN-gamma and IL-4 mRNA positive cells in MS after culture in the presence of AChR, and in MG after culture in the presence of MBP or PLP , did not differ from those detected after culture without antigen