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MET — PLXNB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Hprd Interaction:
MET
—
PLXNB1
(in vivo)
Giordano et al., Nat Cell Biol 2002*
-
IRef Hprd Interaction:
MET
—
PLXNB1
(in vitro)
Giordano et al., Nat Cell Biol 2002*
-
IRef Intact Interaction:
MET
—
PLXNB1
(physical association, anti bait coimmunoprecipitation)
Conrotto et al., Oncogene 2004*
-
IRef Intact Interaction:
MET
—
PLXNB1
(physical association, anti tag coimmunoprecipitation)
Giordano et al., Nat Cell Biol 2002*
-
IRef Intact Interaction:
MET
—
PLXNB1
(phosphorylation reaction, anti tag coimmunoprecipitation)
Giordano et al., Nat Cell Biol 2002*
-
IRef Intact Interaction:
MET
—
PLXNB1
(physical association, anti tag coimmunoprecipitation)
Conrotto et al., Oncogene 2004*
-
IRef Intact Interaction:
MET
—
PLXNB1
(physical association, anti tag coimmunoprecipitation)
Zhou et al., Molecular cancer 2012*
-
IRef Ophid Interaction:
MET
—
PLXNB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
MET
—
PLXNB1
(aggregation, confirmational text mining)
Giordano et al., Nat Cell Biol 2002*
Text-mined interactions from Literome
Giordano et al., Nat Cell Biol 2002
:
In addition, binding of Sema 4D to
Plexin B1 stimulates the tyrosine kinase activity of
Met , resulting in tyrosine phosphorylation of both receptors
Stevens et al., J Invest Dermatol 2010
(Melanoma...) :
Plexin B1 suppresses
c-Met in melanoma : a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met
Sun et al., J Cell Sci 2012
:
Here we show that the
activation of
plexin-B1 by Sema4D and its subsequent tyrosine phosphorylation by
Met creates a docking site for the SH2 domain of growth factor receptor bound-2 (Grb2)
Soong et al., J Cell Sci 2013
:
Plexin B1 inhibits
MET through direct association and regulates Shp2 expression in melanocytes ... We recently showed that Sema4D suppresses activation of the hepatocyte growth factor receptor, MET, in melanocytes, and that knockdown of
Plexin B1 results in activation of
MET ... In this report we investigated the mechanism by which
Plexin B1 inhibits
MET activation