Gene interactions and pathways from curated databases and text-mining

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IL1A — POLDIP2

Text-mined interactions from Literome

Mochida et al., Kokubyo Gakkai Zasshi 2000 (MAP Kinase Signaling System) : Apoptosis signal regulating kinase 1 ( ASK 1 ) is a mitogen activated protein ( MAP ) kinase kinase kinase ( MAPKKK ) that is activated by TNF and IL-1 , and stimulates c-Jun N-terminal kinase ( JNK also known as SAPK ; stress activated protein kinase ) and p38 activation
Lomri et al., J Bone Miner Res 2001 (Acrocephalosyndactylia...) : Moreover, SB203580, a specific inhibitor of p38 mitogen activated protein kinase ( MAPK ), and PD-98059, a specific inhibitor of MAPK kinase ( MEKK ), also reduced IL-1alpha and RhoA expression in Ap cells
Ogata et al., J Dent Res 2007 (MAP Kinase Signaling System...) : IL-1alpha ( PKC ), and PKC inhibitor staurosporine inhibited IL-1alpha induced phosphorylation of ERK1/2, p38 , and JNK, and decreased IL-1alpha induced COX-2 mRNA expression
Busik et al., Diabetes 2008 (Diabetic Retinopathy...) : Exposure of HRECs to 25 mmol/l glucose did not stimulate endogenous ROS production, activation of nuclear factor-kappaB (NF-kappaB), extracellular signal related kinase ( ERK ), p38 and Jun NH ( 2 ) -terminal kinase ( JNK ), tyrosine phosphorylation, interleukin (IL)-1beta , or tumor necrosis factor-alpha (TNF-alpha) production and only slightly affected apoptotic cell death pathways compared with normal glucose ( 5 mmol/l )
Weber et al., Science signaling 2010 : In response to ligand binding of the receptor, a complex sequence of combinatorial phosphorylation and ubiquitination events results in activation of nuclear factor kappaB signaling and the JNK and p38 mitogen activated protein kinase pathways, which, cooperatively, induce the expression of canonical IL-1 target genes ( such as IL-6, IL-8, MCP-1, COX-2, IkappaBalpha, IL-1alpha, IL-1beta, MKP-1 ) by transcriptional and posttranscriptional mechanisms
Eda et al., Rheumatol Int 2011 (MAP Kinase Signaling System) : IL-1ß and TNF-a activated the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 MAPK, p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts
Barbieri et al., Cardiovasc Res 2011 : Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 mitogen activated protein kinase ( p38MAPK ) and Akt mediated either by AS serum or by TS/IL-1ß/TNF-a
Nguyen et al., Neurosignals 2011 (MAP Kinase Signaling System) : IL-1RAcPb deletion had no effect on IL-1a- and IL-1ß induced IL-6 release in neurons, but significantly reduced IL-1a- but not IL-1ß induced p38 phosphorylation
Bose et al., Infect Immun 2012 : Nuclear translocation of pre-IL-1a and IL-1a dependent secretion of IL-8 in response to Yersinia enterocolitica infection were dependent on extracellular signal regulated kinase ( ERK ) and p38 MAP kinase signaling but independent of NF-?B
Sunaga et al., J Vet Med Sci 2012 (MAP Kinase Signaling System) : As a result, in the presence of PPS existence, IL-1ß induced phosphorylation of p38 and ERK were certainly inhibited, while JNK phosphorylation was not affected
Li et al., Life Sci 2012 (Neuroblastoma) : Our results showed that incubation of the supernatant from Aß ( 1-40 ) -stimulated THP-1 cells with SK-N-SH neuroblastoma cells for 24h significantly increased LDH leakage, tau and p-38 phosphorylation in SK-N-SH cells with increased interleukin (IL)-1ß release into the supernatant of THP-1 cells
Kanakaraj et al., J Exp Med 1998 : Here we report that IL-1 mediated activation of JNK, p38 , and NF-kappaB were all reduced in embryonic fibroblasts deficient in IRAK expression