Gene interactions and pathways from curated databases and text-mining

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GTF2B — POLR2J

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Liu et al., Virology 1999 : Human immunodeficiency virus type 1 Tat dependent activation of an arrested RNA polymerase II elongation complex
Lee et al., Mol Cell Biol 1999 : The Mediator complex of Saccharomyces cerevisiae is required for both general and regulated transcription of RNA polymerase II (PolII) and is composed of two stable subcomplexes ( Srb4 and Rgr1 subcomplexes )
Sanders et al., J Biol Chem 1999 : This is the first demonstration that a non-histone-like TAF is required for continuous, high level RNA polymerase II-mediated mRNA gene transcription in living yeast cells
Baskaran et al., Cell Growth Differ 1999 : In vivo, coexpression of a full length CTD prevents c-Abl from inducing the tyrosine phosphorylation of endogenous RNA polymerase II , and such inhibitory effect was not observed with the coexpression of COOH-terminal truncated CTD
Hara et al., J Biol Chem 1999 : Here we investigated the effect of the transcription factor 2 on RNA polymerase II and RNA polymerase I stalled at thymine dimers
Ping et al., J Biol Chem 2001 : DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation
Yamamoto et al., Mol Cell Biol 2001 : Here we demonstrate for the first time that TFIIH mediated phosphorylation of RNA polymerase II (Pol II) is essential for the transition to elongation
Müller et al., Curr Biol 2001 : TBP is not universally required for zygotic RNA polymerase II transcription in zebrafish
Mittler et al., EMBO Rep 2001 : Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
Oelgeschläger et al., J Cell Physiol 2002 : Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control
Westermarck et al., EMBO J 2002 : These findings clarify the mechanism of c-Jun mediated transcriptional regulation, and provide evidence for an involvement of RHII/Gu in stress response and in RNA polymerase II-catalyzed transcription in mammalian cells
Brabazon et al., Biochim Biophys Acta 2002 : Cyclin dependent kinase 8 (cdk8) regulates transcription by phosphorylating RNA polymerase II and TFIIH
Enokido et al., Biochem Biophys Res Commun 2002 : Simultaneously, we showed that mutant ataxin-1 promoted interaction between PQBP-1 and RNA polymerase II and enhanced repression of the basal transcription by PQBP-1
Palancade et al., J Biol Chem 2002 : FCP1 phosphorylation by casein kinase 2 enhances binding to TFIIF and RNA polymerase II carboxyl-terminal domain phosphatase activity
Jansen et al., Nucleic Acids Res 2002 : Transcription elongation factor Spt4 mediates loss of phosphorylated RNA polymerase II transcription in response to DNA damage
Johnson et al., Proc Natl Acad Sci U S A 2002 : GATA-1 induced RNA polymerase II (pol II) recruitment to subregions of the locus control region and to the beta-globin promoters
Sano et al., Nat Med 2002 (Cardiomegaly) : A preferential role for Cdk9 was shown in RNA polymerase II phosphorylation and growth induced by endothelin , using pharmacological and dominant negative inhibitors
Degousee et al., Circ Res 2003 (MAP Kinase Signaling System) : Interleukin-1beta induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter, COX-2 transcription, COX-2 protein synthesis, and prostaglandin E2 ( PGE2 ) release
Shore et al., Gene 2003 : Positive transcription factor b (P-TEFb) is required for RNA polymerase II to make the transition from abortive to productive elongation
Zhou et al., Nucleic Acids Res 2003 : The putative role of RHA-topoisomerase IIalpha complex in RNA polymerase II-mediated transcription is discussed
Grueneberg et al., Mol Cell Biol 2003 : Here, we show for the first time that both UBF1 and UBF2 activate RNA polymerase II-regulated promoters
Wood et al., J Biol Chem 2003 : During the early elongation stage of transcription, the Paf1 complex is required for association of COMPASS with RNA polymerase II , but the role the Paf1 complex plays at the promoter has not been clear ... We also show that Paf1 complex is required for the interaction of Rad6 and COMPASS with RNA polymerase II
Belotserkovskaya et al., Science 2003 : The FACT ( facilitates chromatin transcription ) complex is required for transcript elongation through nucleosomes by RNA polymerase II (Pol II) in vitro
Schwartz et al., Mol Cell Biol 2003 : Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo
Spahr et al., J Biol Chem 2003 : These factors enable RNA polymerase II to initiate transcription from the S. pombe alcohol dehydrogenase promoter ( adh1p ) when combined with Saccharomyces cerevisiae TATA binding protein
Pereira et al., Gene 2003 : Roles for BTAF1 and Mot1p in dynamics of TATA binding protein and regulation of RNA polymerase II transcription ... Roles for BTAF1 and Mot1p in dynamics of TATA binding protein and regulation of RNA polymerase II transcription
Sato et al., Mol Cell 2004 : The Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factors
Sakamoto et al., J Biol Chem 2004 : However, IFNbeta stimulated binding of RNA polymerase II to the ISG54 promoter is prevented by TSA ... However, IFNbeta stimulated binding of RNA polymerase II to the ISG54 promoter is prevented by TSA
Guo et al., Nat Biotechnol 2004 : We identified proteins with links to chromatin functions that interact with acetylated histones, and proteins that participate in RNA polymerase II functions and in CTD phosphorylation regulation that interact preferentially with the phosphorylated CTD
Liu et al., Blood 2004 (Lymphoma) : Our results suggest a model where RNA polymerase II bound at IgH regulatory sequences can activate the cyclin D1 promoter by either long-range polymerase transfer or tracking
Jiang et al., Cell cycle (Georgetown, Tex.) 2004 : Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes
Kim et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : In the final step, Flo8 and Mss11 directly promote association of RNA polymerase II with the STA1 promoter to activate STA1 expression
Wada et al., Biochem Biophys Res Commun 2005 : These data suggest that in addition to epigenetic regulation of constitutive SLPI expression, H3-K4 tri-methylation may play a role in stimulated SLPI expression by modulating RNA polymerase II recruitment and subsequent gene transcription
Cormack et al., Cell 1992 : TBP is required for RNA polymerase II (pol II) transcription from promoters containing conventional TATA elements as well as functionally distinct promoters that lack TATA-like sequences
Usheva et al., Cell 1992 : The specific interaction of RNA polymerase II with TBP was mediated by the CTD of RNA polymerase II
Morillon et al., Mol Cell 2005 : The Isw1 ATPase delays the release of initiated RNA polymerase II (RNAPII) into elongation to facilitate chromatin modifications
Jang et al., Mol Cell 2005 : The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
Laribee et al., Biochim Biophys Acta 2005 : Finally, we show that HDAC activity is required for association of RNA polymerase II with the PU.1 promoter
Takagi et al., J Biol Chem 2006 : Taken together, these findings lead to the suggestion that Mediator is required for basal RNA polymerase II transcription in vivo
Bark-Jones et al., Oncogene 2006 : EBV EBNA 2 stimulates CDK9 dependent transcription and RNA polymerase II phosphorylation on serine 5
Williams et al., EMBO J 2006 (HIV Infections) : Knockdown of p50 expression with specific small hairpin RNAs reduces HDAC1 binding to the latent HIV LTR and induces RNA polymerase II recruitment
Khobta et al., J Mol Biol 2006 : Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells
Radhakrishnan et al., Cancer Res 2006 (Neoplasms...) : Specifically, ARC inhibits the phosphorylation of RNA polymerase II by positive transcription elongation factor-b, leading to a block in transcriptional elongation
Gomez-Roman et al., Biochem Soc Symp 2006 : The activation of RNA polymerase II transcription by c-Myc is often inefficient, but its induction of rRNA and tRNA genes can be very strong in comparison
Giglia-Mari et al., PLoS Biol 2006 : Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair ( NER )
Moisan et al., J Biol Chem 2006 : We recently reported that BRCA1 inhibits RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation by TFIIH and decreases serine 5 phosphorylation levels when introduced into a BRCA1 ( -/- ) cell line
Stevens et al., Med Res Rev 2006 : The Tat-TAR dependent phosphorylation of RNA polymerase II plays an important role in transcriptional elongation as well as in other post-transcriptional events
Soloff et al., Mol Hum Reprod 2006 : Interleukin-1 induced NF-kappaB recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells ... We show further that IL1A reduced RNA polymerase II cross linking to the otr promoter, as reflective of transcriptional inhibition
Crusselle-Davis et al., Mol Cell Biol 2006 : Furthermore, a reduction of USF activity resulted in a significant decrease in acetylated H3, RNA polymerase II , and cofactor recruitment to the locus control region and to the adult beta-globin gene
Vreugde et al., Mol Cell 2006 : Nuclear myosin VI enhances RNA polymerase II-dependent transcription
Yeh et al., Nucleic Acids Res 2006 : The transcription factor ( TF ) Sp1 is a well-known RNA polymerase II transcription activator that binds to GC-rich recognition sites in a number of essential cellular and viral promoters
Yoo et al., J Biol Chem 2007 : A novel role of the actin nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription ... Our recent study indicates that the nuclear localized neural Wiskott-Aldrich syndrome protein ( N-WASP ) can induce de novo actin polymerization in the nucleus, and this function is important for the role of N-WASP in the regulation of RNA polymerase II-dependent transcription
Killeen et al., Mol Cell Biol 1992 : Both partially purified natural RAP30/74 and recombinant RAP30 prevented RNA polymerase II from binding nonspecifically to DNA
Finkelstein et al., Nature 1992 : RAP30/74 or recombinant RAP30 suppresses nonspecific binding of RNA polymerase II to DNA and is required for RNA polymerase II to assemble stably into a preinitiation complex containing promoter DNA and the general factors TFIID, TFIIA and TFIIB ; both RAP30 and RAP74 are physical components of the preinitiation complex
Eeckhoute et al., Cancer Res 2007 (Breast Neoplasms...) : GATA-3 binds to two cis-regulatory elements located within the ER alpha gene, and this is required for RNA polymerase II recruitment to ER alpha promoters
Kenneth et al., Proc Natl Acad Sci U S A 2007 : Activation of RNA polymerase ( pol) II transcription by c-Myc generally involves recruitment of histone acetyltransferases and acetylation of histones H3 and H4
Schnur et al., Biochim Biophys Acta 2007 : However, in the living cell TsA induced Sp1, Sp3 and RNA polymerase II recruitment to the 5-LO promoter without changing the acetylation status of histone protein H4
Oven et al., Mol Cell Biol 2007 : In this study, we found that AIRE regulates the step of elongation rather than initiation of RNA polymerase II
Zager et al., American journal of physiology. Renal physiology 2008 (Acute Kidney Injury...) : Maleate toxicity reproduced critical characteristics of the hypoxia/ATP depletion induced injury cascade : 1 ) glutathione ( GSH ) conferred protection, but due to its glycine, not cysteine ( antioxidant ), content ; 2 ) ATP reductions reflected decreased production, not Na-K-ATPase-driven increased consumption ; 3 ) cell death was completely blocked by extracellular acidosis ( pH 6.6 ) ; 4 ) intracellular Ca ( 2+ ) chelation ( BAPTA ) mitigated cell death ; 5 ) maleate and hypoxia each caused plasma membrane cholesterol shedding and in both instances, this was completely glycine suppressible ; 6 ) maleate + hypoxia caused neither additive NEFA accumulation nor LDH release, implying shared pathogenic pathways ; and 7 ) maleate, like ischemia, induced renal cortical cholesterol loading ; increased HMG CoA reductase (HMGCR) activity ( statin inhibitable ), increased HMGCR mRNA levels, and increased RNA polymerase II recruitment to the HMGCR locus ( chromatin immunoprecipitation, ChIP, assay ) were involved
Ivaldi et al., Genes Dev 2007 : Here we present evidence suggesting that JIl-1 mediated H3S10 phosphorylation is dependent on chromatin remodeling by the brahma complex and is required during early transcription elongation to release RNA polymerase II (Pol II) from promoter-proximal pausing
Farnham et al., Gene Expr 1991 : Sp1 activation of RNA polymerase II transcription complexes involves a heat-labile DNA binding component
Novak Kujundzić et al., J Cell Biochem 2008 : The activity of TOP2A is required for RNA polymerase II transcription on chromatin templates
Gurumurthy et al., J Mol Biol 2008 (Neoplasms) : Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription
Youdell et al., Mol Cell Biol 2008 : Set2 catalyzed H3K36me2 does not require either Ctk1 dependent phosphorylation of RNA polymerase II (RNAPII) or the presence of the phospho-C-terminal domain (CTD) interaction ( SRI ) domain of Set2
Kimura et al., Biochem J 2008 : Thus Cr ( VI ) inhibits mouse MT-I gene expression in response to zinc by interfering with the ability of MTF-1 to form a co-activator complex containing p300 and recruiting RNA polymerase II to the promoter
Xie et al., Proc Natl Acad Sci U S A 2008 : We show by alpha-amanitin inhibition that RNA polymerase II (RNAPII) transcription is required to localize MCM2-7 ( but not ORC ) to permit the second round of origin firing
Reddy et al., Circ Res 2008 (Diabetes Mellitus, Type 2) : Tumor necrosis factor-alpha induced inflammatory gene expression, H3K4me2 levels, and recruitment of RNA polymerase II at the gene promoters were also enhanced in db/db VSMCs, demonstrating the formation of open chromatin poised for transcriptional activation in diabetes
Thiaville et al., Nucleic Acids Res 2008 : It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress
Lejeune et al., DNA repair 2009 : Elc1 has also been suggested to be present in another ubiquitin ligase complex that lacks Rad7 and Rad16 and is involved in UV-induced ubiquitylation and subsequent degradation of RNA polymerase II
Mishiro et al., EMBO J 2009 : The depletion of either CTCF or RAD21 disrupts the chromatin loop structure, together with significant changes in the APO expression and the localization of transcription factor hepatocyte nuclear factor (HNF)-4alpha and transcriptionally active form of RNA polymerase II at the APO promoters ... The depletion of either CTCF or RAD21 disrupts the chromatin loop structure, together with significant changes in the APO expression and the localization of transcription factor hepatocyte nuclear factor (HNF)-4alpha and transcriptionally active form of RNA polymerase II at the APO promoters
Lau et al., Cell cycle (Georgetown, Tex.) 2009 : Hexamethylene bis-acetamide inducible protein 1 ( HEXIM1 ) is an inhibitor of the positive transcription elongation factor b ( P-TEFb ), which controls RNA polymerase II transcription and human immunodeficiency virus Tat transactivation
Benson et al., PloS one 2009 : Using chromatin immunoprecipitation, we found that TLR2 stimulation inhibited IFN-gamma induced RNA polymerase II binding to the CIITA and CXCL11 promoters ... Using chromatin immunoprecipitation, we found that TLR2 stimulation inhibited IFN-gamma induced RNA polymerase II binding to the CIITA and CXCL11 promoters
John et al., J Immunol 2009 (Asthma) : Furthermore, chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and RNA polymerase II to the CXCL8 promoter of asthmatic HASM cells both in the presence and absence of TNF-alpha stimulation
Yu et al., J Biol Chem 2009 : IL-4 also reduced the RANKL induced association of RNA polymerase II with the TRAP gene in osteoclasts ... IL-4 also reduced the RANKL induced association of RNA polymerase II with the TRAP gene in osteoclasts
Takahashi et al., J Biol Chem 2009 : These findings identify an unexpected role for the HNF4alpha DNA binding domain in mediating key regulatory interactions and provide new insights into the roles of HNF4alpha and TFIID in RNA polymerase II transcription ... These findings identify an unexpected role for the HNF4alpha DNA binding domain in mediating key regulatory interactions and provide new insights into the roles of HNF4alpha and TFIID in RNA polymerase II transcription
Kostrewa et al., Nature 2009 : To initiate gene transcription, RNA polymerase II (Pol II) requires the transcription factor IIB ( B )
Sen et al., J Biol Chem 2009 : Finally, inhibition of GSK3beta caused association of RNA polymerase II with the COX2 gene, suggesting transcription initiation
Elmlund et al., Structure 2009 : The general transcription factor IID (TFIID) is required for initiation of RNA polymerase II-dependent transcription at many eukaryotic promoters
Santo et al., Oncogene 2010 (Multiple Myeloma) : AT7519, A novel small molecule multi-cyclin dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition
Schönichen et al., Biochemistry 2010 : Transcription elongation is regulated by the cellular protein Hexim1, which inhibits phosphorylation of RNA polymerase II by interacting with the positive transcription elongation factor P-TEFb
Zhou et al., J Biol Chem 2010 : Here we demonstrate that although USF is required for the efficient association of RNA polymerase II (Pol II) with immobilized LCR templates, USF and NF-E2 together regulate the association of Pol II with the adult beta-globin gene promoter
Guang et al., Nature 2010 : We find that nuclear localized siRNAs direct an NRDE-2 dependent silencing of pre-messenger RNAs ( pre-mRNAs ) 3 ' to sites of RNAi, an NRDE-2 dependent accumulation of RNA polymerase (RNAP) II at genomic loci targeted by RNAi, and NRDE-2 dependent decreases in RNAP II occupancy and RNAP II transcriptional activity 3 ' to sites of RNAi
Heisel et al., BMC molecular biology 2010 : The general transcription factor TFIIF controls the activity of the RNA polymerase II both at the initiation and elongation stages
Carey et al., Cold Spring Harbor protocols 2010 : INTRODUCTION : The Mediator ( Med ) complex plays a key role in promoter-specific activation of transcription by RNA polymerase II (Pol II)
Dermody et al., J Biol Chem 2010 : The Paf1 complex (Paf1C) affects RNA polymerase II transcription by coordinating co-transcriptional chromatin modifications and helping recruit mRNA 3 ' end processing factors
Eilebrecht et al., Nucleic Acids Res 2011 : The highly abundant and essential 7SK ncRNA has been shown to negatively regulate RNA Polymerase II transcription by inactivating the positive transcription elongation factor b ( P-TEFb ) in cellular and Tat dependent HIV transcription
Fuchs-Young et al., Breast Cancer Res Treat 2011 (Cell Transformation, Neoplastic...) : Previous studies from our laboratory have shown that p53 regulates ER expression transcriptionally, by binding the ER promoter and forming a complex with CARM1, CBP, c-Jun, RNA polymerase II and Sp1
Węsierska-Gądek et al., J Cell Biochem 2011 (Breast Neoplasms...) : This inhibition of site-specific modification of CDK7 at Ser164/170 prevented phosphorylation of RNA polymerase II and reduced basal phosphorylation of ER-a at Ser118 in non stimulated MCF-7 cells ( resulting in its down-regulation )
Larschan et al., Nature 2011 : Here we use global run-on sequencing ( GRO-seq ) to examine the specific effect of the MSL complex on RNA Polymerase II (RNAP II) on a genome-wide level
Zheng et al., Plant Cell 2011 : We show that these apc/c mutants had reduced miR159 levels and increased DUO1 and CYCB1 ; 1 transcript levels and that APC/C is required to recruit RNA polymerase II to MIR159 promoters ... We show that these apc/c mutants had reduced miR159 levels and increased DUO1 and CYCB1 ; 1 transcript levels and that APC/C is required to recruit RNA polymerase II to MIR159 promoters
Zhang et al., Carcinogenesis 2011 (Pancreatic Neoplasms) : miR-132 was transcribed by RNA polymerase II , and Sp1 played a major role in miR-132 transcription
Flynn et al., Proc Natl Acad Sci U S A 2011 : Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome
Ansari et al., J Mol Biol 2011 : MLL2 and MLL3 play key roles in histone H3 lysine-4 trimethylation and in the recruitment of general transcription factors and RNA polymerase II in the HOXC6 promoter during E2-dependent transactivation ... MLL2 and MLL3 play key roles in histone H3 lysine-4 trimethylation and in the recruitment of general transcription factors and RNA polymerase II in the HOXC6 promoter during E2-dependent transactivation
Žumer et al., Nucleic Acids Res 2011 (Polyendocrinopathies, Autoimmune) : Via P-TEFb, AIRE increased levels of RNA polymerase II on and enhanced pre-mRNA splicing of heterologous and endogenous target genes
Choukrallah et al., Nucleic Acids Res 2012 : The TATA binding protein (TBP) plays a pivotal role in RNA polymerase II (Pol II) transcription through incorporation into the TFIID and B-TFIID complexes
Freeman et al., Gastroenterology 2012 (Adenocarcinoma...) : Inhibition of BMP or depletion of Smad4 in HEK293T cells increased binding of RNA polymerase II to the ß-catenin gene ... Inhibition of BMP or depletion of Smad4 in HEK293T cells increased binding of RNA polymerase II to the ß-catenin gene
Bah et al., Nucleic Acids Res 2012 : RNA polymerase II (RNAPII) associates with pombe chromosome ends in vivo and the telomeric factor Rap1 negatively regulates this association, as well as the cellular accumulation of RNA emanating from chromosome ends
Ramamoorthi et al., Science 2011 : By recruiting RNA polymerase II to promoters and enhancers of target genes, Npas4 regulates a learning-specific transcriptional program in CA3 that includes many well-known activity regulated genes, which suggests that Npas4 is a master regulator of activity regulated gene programs and is central to memory formation
Meier et al., Endocrinology 2012 : The recruitment of these transcription factors to the STAR proximal promoter results in association of CBP and activation of RNA polymerase II leading to increased STAR transcription
Lu et al., Cancer Cell 2012 (Cell Transformation, Neoplastic...) : CREPT regulates cyclin D1 expression by binding to its promoter, enhancing its transcription both in vivo and in vitro, and interacting with RNA polymerase II (RNAPII)
Guillamot et al., Scientific reports 2011 : Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
Iglesias et al., PloS one 2012 (Inflammation) : We examined the effect of 2 hrs LPS stimulation on early gene expression and its relation to chromatin remodeling ( H3 acetylation ; H3Ac ) and promoter binding of Sp1 and RNA polymerase II phosphorylated at serine 5 ( S5P RNAPII ), which is a marker for transcriptional initiation
Ernest et al., J Biol Chem 1978 : The RNA polymerase II inhibitor, alpha-amanitin, completely blocked the dibutyryl cyclic AMP mediated increase in tyrosine aminotransferase mRNA activity
Tripathi et al., Mol Biol Cell 2012 : Furthermore, on a stably integrated reporter gene locus, we demonstrate the role of SRSF1 in RNA polymerase II-mediated transcription
Manzo et al., Cancer Res 2012 (Neoplasms) : Natural product triptolide mediates cancer cell death by triggering CDK7 dependent degradation of RNA polymerase II
García et al., Mol Biol Cell 2012 : In addition, Sub1 globally regulates RNA polymerase II phosphorylation, and most recently it has been shown that it is a functional component of the preinitiation complex
Zhang et al., J Biol Chem 2012 : Bromodomain containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells
Chymkowitch et al., Transcription 2013 : Here, we discuss the biological significance of this finding and give our view of the kinase dependent role of Cdc28 in regulation of RNA polymerase II
Wagner et al., J Virol 2013 : Affinity purification experiments demonstrated that d3-10 ICP4 was not found in complexes with components of TFIID and mediator, suggesting that the defect in RNA polymerase II (Pol II) recruitment was the result of ablated interactions between d3-10 and TFIID and mediator
Sainsbury et al., Nature 2013 : The general transcription factor (TF) IIB is required for RNA polymerase (Pol) II initiation and extends with its B-reader element into the Pol II active centre cleft
Zhang et al., PloS one 2012 (Eosinophilic Esophagitis) : Rather, omeprazole blocked binding of IL-4 stimulated STAT6, RNA polymerase II , and trimethylated H3K4 to the eotaxin-3 promoter
Ansari et al., Mol Endocrinol 2013 : MLL1 and MLL2 bind to SR-B1 promoter in an E2-dependent manner and control the assembly of transcription pre-initiation complex and RNA polymerase II (RNAPII) recruitment ... MLL1 and MLL2 bind to SR-B1 promoter in an E2-dependent manner and control the assembly of transcription pre-initiation complex and RNA polymerase II (RNAPII) recruitment
Zeng et al., Biology open 2012 : Upon hypoxia, TLX increases in the nucleus where it binds in close proximity of the HIF-response element on the VEGF-promoter chromatin, and, together with HIF-2a, recruits RNA polymerase II to induce VEGF expression
Ladopoulos et al., Mol Cell Biol 2013 : The Histone Methyltransferase KMT2B Is Required for RNA Polymerase II Association and Protection from DNA Methylation at the MagohB CpG Island Promoter ... We demonstrate that in the presence of KMT2B , neither transcription elongation nor RNA polymerase II binding is required to maintain H3K4 trimethylation at the MagohB promoter and protect it from DNA methylation
Sen et al., J Biol Chem 2013 : In contrast, the loss of Rad6p significantly impairs the association of RNA polymerase II with GAL1
Samaranayake et al., PloS one 2013 : Role of Ess1 in Growth, Morphogenetic Switching, and RNA Polymerase II Transcription in Candida albicans
Kang et al., Journal of proteomics 2013 : Basic transcription factor 3 (BTF3) is involved in the transcriptional initiation of RNA polymerase II and is also associated with apoptosis
Kassube et al., Nature structural & molecular biology 2013 : Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5
Bi et al., Biochim Biophys Acta 2013 : H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U-actin complex ... H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U-actin complex
Bowman et al., Development 2013 : Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline
Kitajima et al., Nucleic Acids Res 1990 : A heteromeric transcription factor required for mammalian RNA polymerase II
Ghosh-Roy et al., PloS one 2013 : Rad26 , the Transcription Coupled Repair Factor in Yeast, Is Required for Removal of Stalled RNA Polymerase-II following UV Irradiation
Egyházi et al., Mol Cell Biol 1987 : Anti-topoisomerase I IgG had less effect on RNA polymerase II-promoted activity of other less efficiently transcribing heterogeneous nuclear RNA genes
Bartolomei et al., Mol Cell Biol 1988 : We concluded that the CTD is essential for RNA polymerase II activity, since substantial mutations in this region result in loss of function
Egyházi et al., Chromosoma 1986 : Selective repression of RNA polymerase II by microinjected phosvitin
Bitter et al., Nucleic Acids Res 1979 (Plasmacytoma) : However, the Mg2+ as divalent cation, the proportion of the total RNA which represents viral gene transcripts is increased 3- to 4-fold with RNA polymerase II , while it remains unchanged for RNA polymerases I or III
Wujcik et al., J Virol 1984 (Plasmacytoma) : Low concentrations of alpha-amanitin ( 2 micrograms/ml ) inhibited IAP RNA synthesis by greater than 90 %, suggesting that RNA polymerase II is responsible for IAP transcription
Duyster et al., Proc Natl Acad Sci U S A 1995 : Src homology 2 domain as a specificity determinant in the c-Abl mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain
Wu-Baer et al., Proc Natl Acad Sci U S A 1995 : Specific binding of RNA polymerase II to the human immunodeficiency virus trans activating region RNA is regulated by cellular cofactors and Tat
Garrett et al., Proc Natl Acad Sci U S A 1995 : Taken together, these findings establish a role for p18 in regulating the activity of the RNA polymerase II elongation complex, and they bring to light a function for a UbH domain protein in transcriptional regulation
Valay et al., J Mol Biol 1995 : Thus, the Kin28 gene product is required in vivo for RNA polymerase II phosphorylation and transcriptional activity as recently suggested by experiments using an in vitro reconstituted system
Parvin et al., J Biol Chem 1994 : As had been observed for the TATA binding protein (TBP) subunit ( Parvin and Sharp, 1993 ), transcription from the IgH promoter minimally requires TFIID activity plus TFIIB and RNA polymerase II
Ohkuma et al., Nature 1994 : We demonstrate that extensive phosphorylation of RNA polymerase II occurs in a TFIIE dependent manner in both the absence and presence of DNA but, in the latter case, only at a late stage of preinitiation complex assembly
Guzder et al., Nature 1994 : Extract from the conditional lethal mutant rad25-ts24 exhibits a thermolabile transcriptional defect which can be corrected by the addition of RAD25 protein, indicating a direct and essential role of RAD25 in RNA polymerase II transcription
Goodrich et al., Cell 1993 : Enhancement of RNA polymerase II transcription by the viral transactivator VP16 requires the TFIID complex , which consists of the TATA binding protein (TBP) and TBP associated factors (TAFs)
Das et al., J Biol Chem 1993 : These two proteins differ in the types of octamer motif containing promoters they preferentially activate ; Oct-1 can activate RNA polymerase II transcription from a small nuclear RNA promoter better than Oct-2, which can better activate an mRNA-type promoter
Weinzierl et al., EMBO J 1993 : Regulation of transcription initiation by RNA polymerase II requires TFIID , a multisubunit complex composed of the TATA binding protein (TBP) and at least seven tightly associated factors ( TAFs )
Conaway et al., Cell Mol Biol Res 1993 : Here we describe the properties of SIII as well as its role in regulating the activity of the RNA polymerase II elongation complex
Sadowski et al., Genes Dev 1993 : We show here, however, that TBP activates transcription from RNA polymerase II snRNA promoters through a non-TATA box element, the snRNA proximal sequence element ( PSE ), as part of a new snRNA activating protein complex (SNAPc)
Wu-Baer et al., J Biol Chem 1996 : Recombinant EF-1alpha, PTB , and SRB produced from vaccinia expression vectors stimulated the binding of RNA polymerase II and TRP-185 to TAR RNA in gel retardation analysis
Tong et al., Mol Cell Biol 1996 : To dissect the role of the LBD in receptor mediated silencing, we used a cell-free transcription system containing HeLa nuclear extracts in which exogenously added unliganded TRbeta repressed the basal level of RNA polymerase II-driven transcription from a thyroid hormone response element linked template
Dvir et al., J Biol Chem 1996 : A role for ATP and TFIIH in activation of the RNA polymerase II preinitiation complex prior to transcription initiation
Sadowski et al., Proc Natl Acad Sci U S A 1996 : SNAP45 is exceptionally proline-rich, interacts strongly with TBP, and, like SNAP43, is required for both RNA polymerase II and III transcription of snRNA genes
Shaw et al., Mol Cell Biol 1996 : The general transcription factor IIB ( TFIIB ) is required for RNA polymerase II transcription in eukaryotes ... The general transcription factor IIB ( TFIIB ) is required for RNA polymerase II transcription in eukaryotes
Mavankal et al., Proc Natl Acad Sci U S A 1996 : These studies are consistent with the model that RNA polymerase II is a cellular target for Tat resulting in Tat mediated increases in transcriptional elongation from the HIV long terminal repeat
Wu-Baer et al., EMBO J 1995 : The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA
Jacob et al., Gene Expr 1996 : GAL4-VP16 stimulates two RNA polymerase II promoters primarily at the preinitiation complex assembly step
Lees-Miller et al., J Virol 1996 : As ICP0 acts as a promoter independent transactivator of gene expression, these data suggest that ICP0 may function by directly or indirectly targeting the p350/DNA-PKcs subunit of DNA-PK, thereby altering the inhibitory effects of DNA-PK on RNA polymerase II transcription
Baskaran et al., J Biol Chem 1997 : The processive and high stoichiometric phosphorylation of RNA polymerase II by c-Abl requires the tyrosine kinase, the SH2 domain, and a CTD interacting domain (CTD-ID) in the Abl protein
Dvir et al., Proc Natl Acad Sci U S A 1997 : In this report, we present direct evidence that TFIIH also controls RNA polymerase II activity at a postinitiation stage of transcription, by preventing premature arrest by very early elongation complexes just prior to their transition to stably elongating complexes
Hamilton et al., J Biol Chem 1997 : RNA polymerase II inhibition increased the binding of ARE ( AUBP activity ) and poly ( U ) -Sepharose by cytoplasmic hnRNP A1 , while nuclear hnRNP A1 binding was unaffected
Pagtakhan et al., Virology 1997 : We suggest that these interactions, rather than direct Tat/Sp1 binding, result in highly processive RNA polymerase II complexes and full-length viral transcripts ... We suggest that these interactions, rather than direct Tat/Sp1 binding, result in highly processive RNA polymerase II complexes and full-length viral transcripts
Chicca et al., Mol Cell Biol 1998 : TAF-172 inhibits TBP-driven RNA polymerase II and III transcription but does not appear to affect transcription driven by TBP-TAF complexes
Serizawa et al., J Biol Chem 1998 : Cyclin dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH
Perretta et al., Arch Biol Med Exp (Santiago) 1979 : Using alpha-amanitine and different ionic strength conditions it was found that erythropoietin enhances preferentially RNA polymerase II activity while testosterone increases RNA polymerase I activity
Palmero et al., Ital J Biochem 1998 : Direct stimulatory effects of insulin-like growth factor-I (IGF-I) on nuclear RNA polymerase II activity and overall protein synthesis in immature rat Sertoli cells
Wada et al., EMBO J 1998 : Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro
Han et al., Mol Cell Biol 1999 : The multisubunit Mediator complex of Saccharomyces cerevisiae is required for most RNA polymerase II (Pol II) transcription