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NFKBIA — PPARA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Delerive et al., Mol Endocrinol 2002
:
Site directed mutagenesis experiments revealed that
PPARalpha activation of
IkappaBalpha transcription requires the NF-kappaB and Sp1 sites within IkappaBalpha promoter ... Overexpression of the oncoprotein E1A failed to inhibit
PPARalpha mediated
IkappaBalpha promoter induction, suggesting that cAMP response element binding protein binding protein/p300 is not involved in this mechanism ... Taken together, these data provide a molecular basis for
PPARalpha mediated induction of
IkappaBalpha and demonstrate, for the first time, that PPARalpha may positively regulate gene transcription in the absence of functional PPAR response elements
Kleemann et al., Blood 2003
:
First,
PPAR-alpha increases
IkappaB-alpha expression and thus prevents p50-NFkappaB translocation to the nucleus
Buroker et al., FEBS J 2009
:
In conclusion, our study revealed that
PPAR regulates the mouse cardiac
IkappaBalpha gene in both control and transgenic mouse heart