Hwang et al., J Neurochem 2002
:
These results suggest that NADPH oxidase and nNOS contribute to increased oxidative stress, subsequent activation of PARP/PARG , and neuronal death induced by prolonged neurotrophin exposure
Kurabayashi et al., Nihon rinsho. Japanese journal of clinical medicine 2005
(Fibrosis...) :
Published studies have shown that PPARgamma ligands can attenuate the expression or activity of NADPH oxidase subunits
Umeji et al., Am J Physiol Heart Circ Physiol 2006
(Hypercholesterolemia) :
Pitavastatin restored both Cu/ZnSOD activity ( P < 0.005 ) and PPAR-gamma expression and activity ( P < 0.01 ) and inhibited NAD ( P ) H oxidase activity ( P < 0.0001 ) in the aorta, whereas probucol inhibited NAD ( P ) H oxidase activity more than did pitavastatin ( P < 0.0005 ) without affecting Cu/ZnSOD activity or PPAR-gamma expression and activity
Qin et al., J Cell Physiol 2009
(Coronary Restenosis) :
These data demonstrate that upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis and activation of PPAR-gamma can inhibit the NADPH oxidase dependent superoxide generation in SMCs after injury