Gene interactions and pathways from curated databases and text-mining

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PRKAB1 — SOCS3

Text-mined interactions from Literome

Ko et al., Diabetes 2009 (Diabetic Angiopathies...) : Acute physiological elevation of IL-6 suppressed glucose metabolism and caused insulin resistance by increasing SOCS3 and via SOCS3 mediated inhibition of insulin receptor substrate (IRS)-1 and possibly AMPK in heart
Kim et al., Diabetologia 2012 (Insulin Resistance) : IL-6 induced STAT3 transactivation and SOCS3 production were significantly repressed by metformin, adenoviral constitutively active AMPK ( Ad-CA-AMPK ), and adenoviral SHP ( Ad-SHP ), but not in Shp knockdown, or with the adenoviral dominant negative form of AMPK ( Ad-DN-AMPK )
Wan et al., PloS one 2012 : Treatment of cultured epididymal adipose tissue ( eWAT ) with IL-6 ( 150 ng/ml ) increased the phosphorylation of AMPK , ACC and STAT3 and induced SOCS3 mRNA levels while decreasing PEPCK and PDK4 mRNA