Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — PRKAG1

Text-mined interactions from Literome

Canabal et al., Am J Physiol Regul Integr Comp Physiol 2007 (Acute Disease...) : Hyperglycemia induced inhibition of AMPK reduces PI3K signaling by activating the mammalian target of rapamycin (mTOR)
Huang et al., Int J Cardiol 2009 (Atherosclerosis) : Metformin inhibits TNF-alpha induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K dependent AMPK phosphorylation ... This effect was related to PI3K dependent AMPK phosphorylation
Zhang et al., Biol Pharm Bull 2010 (Insulin Resistance) : Moreover, 7-O-MA stimulated the reactivation of insulin mediated phosphorylation of phosphatidylinositol 3-kinase (PI3K) linked protein kinase B ( Akt/PKB ) and adenosine 5'-monophosphate activated protein kinase ( AMPK ) in high glucose induced, insulin-resistant HepG2 cells, and this effect was blocked by either LY294002, a PI3K inhibitor, or compound C, an AMPK inhibitor
Hien et al., Mol Pharmacol 2011 : Moreover, AMPK inhibition significantly reversed the activation of ER-dependent transcription and PI3K activation in response to nectandrin B. Nectandrin B evoked endothelium dependent relaxation in rat aortic rings, and this was blocked by inhibition of AMPK , ER, or PI3K
Zong et al., PloS one 2012 (MAP Kinase Signaling System) : Meanwhile, PI3-K is essential for resveratrol mediated phosphorylation of AMPK and expression of SIRT1
Hien et al., Biochem Pharmacol 2012 : ER inhibition reversed AMPK dependent PI3K activation in response to amurensin G. Amurensin G-mediated endothelium dependent relaxation was blocked by inhibition of AMPK, ER, Src, or PI3K
Suzuki et al., Mol Cell 2013 : Surprisingly, PI3K-Akt signaling, which is a major anabolic signaling and normally inhibits GSK3 activity, promotes GSK3 phosphorylation and inhibition of AMPK , thus revealing how AMPK senses anabolic environments in addition to cellular energy levels
Ji et al., PloS one 2013 : Moreover, the PI3K inhibitor wortmannin significantly inhibited activation of Akt and AMPK , reduced GLUT4 translocation, glucose uptake and ultimately, depressed IPC induced cardioprotection