Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — PRKCA

Text-mined interactions from Literome

Sukumaran et al., J Biol Chem 2002 : This is the first report of FAK- and PI3K dependent PKC-alpha activation in bacterial invasion related to cytoskeletal reorganization
Oh et al., J Biol Chem 2003 : PI3K activation is required for the activation of protein kinase C (PKC)-alpha and p38 kinase and inhibition of ERK1/2
Hardy et al., Immunology 2009 : However, PKC-alpha phosphorylation was independent of PI3K and p38 MAPK, indicating that IFN-gamma induced phosphorylation and nuclear translocation of PKC-alpha are mediated by distinct mechanisms ... Taken together, our data indicate that PI3K and p38 MAPK modulate IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both PI3K and PKC-alpha are required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages
Yan et al., J Cell Biochem 2010 (Cardiomegaly) : The inhibitory effect of breviscapine on cardiac hypertrophy is mediated by disrupting PKC-alpha dependent ERK1/2 and PI3K/AKT signaling
Lee et al., J Cell Physiol 2010 (MAP Kinase Signaling System) : Taken together, these data suggest that in A549 cells, TNF-alpha induces MMP-9 expression via the TNFR1/TRAF2/PKCalpha dependent JNK1/2/c-Jun and c-Src/EGFR/PI3K/Akt pathways
Rotman et al., Reproduction 2010 : Previously, we reported that short-time activation of protein kinase A ( PRKA, PKA ) leads to PI3K activation and protein kinase C(alpha) ( PRKCA, PKC(alpha) ) inhibition ... Moreover, inhibition of PRKCA causes significant activation of PI3K