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PIK3R1 — PRKCA
Text-mined interactions from Literome
Sukumaran et al., J Biol Chem 2002
:
This is the first report of FAK- and
PI3K dependent
PKC-alpha activation in bacterial invasion related to cytoskeletal reorganization
Oh et al., J Biol Chem 2003
:
PI3K activation is
required for the activation of
protein kinase C (PKC)-alpha and p38 kinase and inhibition of ERK1/2
Hardy et al., Immunology 2009
:
However,
PKC-alpha phosphorylation was
independent of
PI3K and p38 MAPK, indicating that IFN-gamma induced phosphorylation and nuclear translocation of PKC-alpha are mediated by distinct mechanisms ... Taken together, our data indicate that
PI3K and p38 MAPK modulate IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both PI3K and
PKC-alpha are
required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages
Yan et al., J Cell Biochem 2010
(Cardiomegaly) :
The inhibitory effect of breviscapine on cardiac hypertrophy is mediated by disrupting
PKC-alpha dependent ERK1/2 and
PI3K/AKT signaling
Lee et al., J Cell Physiol 2010
(MAP Kinase Signaling System) :
Taken together, these data suggest that in A549 cells, TNF-alpha induces MMP-9 expression via the
TNFR1/TRAF2/PKCalpha dependent JNK1/2/c-Jun and
c-Src/EGFR/PI3K/Akt pathways
Rotman et al., Reproduction 2010
:
Previously, we reported that short-time activation of protein kinase A ( PRKA, PKA ) leads to
PI3K activation and
protein kinase C(alpha) ( PRKCA, PKC(alpha) )
inhibition ... Moreover, inhibition of
PRKCA causes significant activation of
PI3K