Gene interactions and pathways from curated databases and text-mining

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PRKCA — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shih et al., Mol Cancer Ther 2004 (Prostatic Neoplasms) : An inhibitor of protein kinase C (PKC)-alpha , -beta, and -gamma ( CGP41251 ) enhanced Ser15 phosphorylation of p53 by resveratrol in the absence of EGF and blocked EGF inhibition of the resveratrol effect
Zhan et al., J Biol Chem 2005 (Neovascularization, Pathologic) : Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation ... In the present study, we found that PKCalpha protein expression is inhibited by WT p53 partly due to reduced PKCalpha mRNA expression in STS cells, but p53 does not affect PKCalpha mRNA stability ... Deletion and mutation analysis of the PKCalpha promoter fused to the luciferase reporter gene identified a Sp1 binding site ( -244/-234 ) in the PKCalpha promoter that is required for p53 mediated inhibition of PKCalpha promoter activity
Coutinho et al., FEBS Lett 2009 : Whereas PKC-alpha reduced the p53 induced yeast growth inhibition and cell cycle arrest, PKC-delta and -epsilon enhanced the p53 activity through p53 phosphorylation, and PKC-zeta had no effect on p53