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PRKCA — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Hprd Interaction:
TP53
—
PRKCA
(in vitro)
Baudier et al., Proc Natl Acad Sci U S A 1992*, Youmell et al., Biochem Biophys Res Commun 1998*, Hasan et al., Int J Cancer 1999*
-
IRef Hprd Interaction:
TP53
—
PRKCA
(in vivo)
Baudier et al., Proc Natl Acad Sci U S A 1992*, Youmell et al., Biochem Biophys Res Commun 1998*, Hasan et al., Int J Cancer 1999*
-
IRef Ophid Interaction:
PRKCA
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
PRKCA
—
TP53
(aggregation, confirmational text mining)
Hasan et al., Int J Cancer 1999*
Text-mined interactions from Literome
Shih et al., Mol Cancer Ther 2004
(Prostatic Neoplasms) :
An inhibitor of
protein kinase C (PKC)-alpha , -beta, and -gamma ( CGP41251 )
enhanced Ser15 phosphorylation of
p53 by resveratrol in the absence of EGF and blocked EGF inhibition of the resveratrol effect
Zhan et al., J Biol Chem 2005
(Neovascularization, Pathologic) :
Transcriptional
repression of
protein kinase Calpha via Sp1 by wild type
p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation ... In the present study, we found that
PKCalpha protein expression is
inhibited by WT
p53 partly due to reduced PKCalpha mRNA expression in STS cells, but p53 does not affect PKCalpha mRNA stability ... Deletion and mutation analysis of the PKCalpha promoter fused to the luciferase reporter gene identified a Sp1 binding site ( -244/-234 ) in the PKCalpha promoter that is required for
p53 mediated inhibition of
PKCalpha promoter activity
Coutinho et al., FEBS Lett 2009
:
Whereas
PKC-alpha reduced the p53 induced yeast growth inhibition and cell cycle arrest, PKC-delta and -epsilon
enhanced the
p53 activity through p53 phosphorylation, and PKC-zeta had no effect on p53