Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — PRL

Text-mined interactions from Literome

Domínguez-Cáceres et al., Oncogene 2004 : Activation of the PI3K by PRL was necessary for the expression of c-MycmRNA and W53 cell proliferation, as the PI3K inhibitor LY294002 abolished them
Romano et al., Endocrinology 2006 : Although the PRL promoter was not affected by either PI3K/Akt inhibition or activation, PRL release increased in response to the pharmacological PI3K/Akt inhibitors in unstimulated GH4C1 and rat pituitary primary cells
Hügl et al., JOP : Journal of the pancreas 2007 (Insulinoma) : PI3'K activation was essential for prolactin and glucose stimulated INS-1 cell proliferation
Di Rosa et al., J Cell Biochem 2009 (MAP Kinase Signaling System) : Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K , and MAPK pathways
Chen et al., Genes Dev 2012 : Surprisingly, we found that mammary differentiation was due to the PI3K-Akt dependent synthesis and secretion of autocrine prolactin and downstream activation of the prolactin receptor (Prlr)-Jak-Stat5 pathway ... Our findings reveal that PI3K-Akt pathway activation is necessary and sufficient to induce autocrine prolactin production in the mammary gland, Stat5 activation, and terminal mammary epithelial differentiation, even in the absence of the normal developmental program that prepares the mammary gland for lactation