Unterholzner et al., PLoS Pathog 2011
:
Thus C6 contributes to VACV virulence and might do so via the inhibition of PRR induced activation of IRF3 and IRF7
Doehle et al., J Virol 2012
:
Interferon regulatory factor 3 (IRF3) plays a central role in PRR signaling of innate immunity to drive the expression of type I interferon ( IFN ) and interferon stimulated genes ( ISGs ), including a variety of HIV restriction factors, that serve to limit viral replication directly and/or program adaptive immunity
Doehle et al., J Virol 2012
:
IRF3 plays a major role in pathogen recognition receptor ( PRR ) signaling of innate immunity to drive the expression of type I interferon ( IFN ) and interferon stimulated genes ( ISGs ), including a variety of HIV restriction factors, that serve to limit viral replication directly and/or program adaptive immunity