Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

PIK3R1 — PSEN1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Baki et al., EMBO J 2004 (Alzheimer Disease...) : PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation : effects of FAD mutations ... Furthermore, conditions that inhibit this association prevent the PS1 induced PI3K/Akt activation , indicating that PS1 stimulates PI3K/Akt signaling by promoting cadherin/PI3K association ... PS1 FAD mutations inhibit the PS1 dependent PI3K/Akt activation, thus promoting GSK-3 activity and tau overphosphorylation at AD-related residues
Baki et al., J Neurosci 2008 (Alzheimer Disease...) : Expression of exogenous WT PS1 or constitutively active Akt in PS1-/- neurons stimulates PI3K signaling and suppresses both caspase-3 activity and dendrite retraction