Gene interactions and pathways from curated databases and text-mining

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PTCH1 — TCF15

Text-mined interactions from Literome

Rahnama et al., Biochem J 2006 : PTCH1 mediates its effects through SMO ( Smoothened ) and represses the expression of HH target genes such as the transcription factor GLI1 ( glioma 1 ) as well as PTCH1
Akimaru et al., Nature 1997 : cubitus interruptus ( ci ), a component in hh signalling, encodes a transcription factor homologous to the Gli family of proteins and is required for induction of the hh-dependent expression of patched (ptc) , decapentaplegic ( dpp ) and wingless ( wg )