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AGTR1 — PTGS2

Text-mined interactions from Literome

Höcherl et al., Pflugers Arch 2001 : Renocortical expression of renin and of cyclooxygenase-2 in response to angiotensin II AT1 receptor blockade is closely coordinated but not causally linked
Zhang et al., Proc Natl Acad Sci U S A 2006 : In summary, these results demonstrate that macula densa COX-2 expression is oppositely regulated by AT(1) and AT(2) receptors and suggest that AT(2) receptor mediated cortical COX-2 elevation may mediate physiologic effects that modulate AT(1) mediated responses
Morinelli et al., Biochim Biophys Acta 2008 : These results demonstrate that inhibiting the internalization of the AT1AR results in a loss of ability of Angiotensin II to increase the protein expression of COX-2, thus supporting previous work showing a relationship between AT1AR nuclear localization and activation of COX-2 gene expression
Pham et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells
Jensen et al., American journal of physiology. Renal physiology 2010 (Reperfusion Injury) : Therefore, we speculated whether the effects of AT1R blockade on V2R and the vasopressin regulated pathway are attributable to attenuated COX-2 induction
Lemos et al., PloS one 2012 : Enalapril, losartan, indomethacin, furegrelate, the selective COX-2 inhibitor NS 398, superoxide dismutase and the NADPH oxidase inhibitor apocynin reverted HgCl ( 2 ) effects on the reactivity to phenylephrine, COX-2 protein expression was increased, and AT1 expression reduced
Gonzalez et al., Hypertension 2013 (MAP Kinase Signaling System) : Importantly, rat recombinant prorenin upregulated COX-2 expression in the presence of AT(1)R blockade
Morinelli et al., Am J Physiol Cell Physiol 2013 : Activation of the angiotensin type 1A receptor (AT1AR) in rat aorta vascular smooth muscle cells ( RASMC ) results in increased synthesis of the proinflammatory enzyme cyclooxygenase-2 (COX-2)
Mangat et al., J Clin Invest 1997 (Hypercalcemia) : To determine if AT1 angiotensin II receptor activation was involved in the stimulation of cPLA2 and PGHS-2 in hypercalcemia, we treated rats with the AT1 receptor antagonist, losartan ... To determine if AT1 angiotensin II receptor activation was involved in the stimulation of cPLA2 and PGHS-2 in hypercalcemia, we treated rats with the AT1 receptor antagonist, losartan