Gene interactions and pathways from curated databases and text-mining

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PLA2G1B — PTGS2

Text-mined interactions from Literome

Lin et al., Br J Pharmacol 1999 : 6. This is the first report that the PLA2 inhibitor, MAFP, can induce COX-2 gene expression and PGE2 synthesis via the PKC-, ERK- and p38 MAPK dependent pathways
Yuan et al., Cancer Res 2000 : Pancreatic secretory PLA2 ( sPLA2 ), via its receptor ( sPLA2R ), transcriptionally activates COX-2 gene expression in several cell types, although a specific transcription factor mediating COX-2 expression has not yet been identified
Schmidlin et al., Naunyn Schmiedebergs Arch Pharmacol 2000 : PLA2 phosphorylation and cyclooxygenase-2 induction , through p38 MAP kinase pathway, is involved in the IL-1beta induced bradykinin B2 receptor gene transcription
Hermoso et al., Pflugers Arch 2001 : Minimal doses of PAF trigger Ca2+ mobilization in tandem with increased PLA2 activity and a COX-2 mediated increase in PGE2
Moreira et al., Eur J Pharmacol 2013 : Inhibition of cytosolic PLA2 (cPLA2), but not Ca ( 2+ ) independent PLA2 ( iPLA2 ) reduced release of PGD2 and PGE2 and expression of COX-2 induced by MT-II
Roshak et al., J Rheumatol 1996 (Arthritis, Rheumatoid) : The antisense effect was specific, since it did not affect 14 kDa PLA2 activity released into the media or induced cyclooxygenase II protein levels over 24 h. Antisense, but not sense, reduced PGE2 formation in a concentration dependent manner
Tada et al., J Immunol 1998 : A type IIA sPLA2 inhibitor, but neither cytosolic PLA2 nor COX inhibitors, reduced, while adding exogenous type IIA sPLA2 augmented , NGF induced COX-2 expression and its attendant PGD2 generation, indicating that the sPLA2 mediated increase in delayed PGD2 generation was attributable mainly to enhanced COX-2 expression