Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — PTH

Text-mined interactions from Literome

Gentili et al., J Cell Biochem 2002 (MAP Kinase Signaling System) : PTH dose- and time-dependently increased PI3K activity with a peak occurring at 2 min ... We report here that PI3K is also required for PTH activation of the mitogen activated protein kinases ERK1 and ERK2 ... Taken together, the present study demonstrate, for the first time, that PTH rapidly and transiently stimulates PI3K activity and its down effector Akt/PKB in rat enterocytes playing c-Src kinase a central role in PTH dependent PI3K activation and that PI3K signaling pathway contributes to PTH mediated MAPK activation
Gentili et al., Biochim Biophys Acta 2003 : Intracellular Ca ( 2+ ) chelation ( BAPTA-AM, 5 microM ) affected the tyrosine phosphorylation of p85alpha and inhibited PTH dependent PI3K activation by 75 % in young rats and completely abolished the enzyme activity in aged animals, demonstrating that Ca ( 2+ ) is required for full activation of PI3K in enterocytes stimulated with PTH