Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — PTK2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ling et al., J Cell Biochem 1999 (Astrocytoma) : Our data suggest a role for PI3-K and p125FAK complex formation in PI3-K activation
Li et al., American journal of physiology. Renal physiology 2006 : We conclude that PI3K is involved in mediating the effect of low K intake on ROMK channel activity in the CCD and that the effect of PI3K on SK channels requires the involvement of PTK and the cytoskeleton
Hehlgans et al., Int J Radiat Biol 2007 : On the basis of the presented data, a precise correlation of adhesion-, serum- and PI3K mediated changes in PI3K/AKT and FAK/Paxillin/p130Cas signaling cascades was not found
Weidenaar et al., Mol Cancer Res 2013 (Leukemia, Myeloid, Acute...) : Proteome profiler array analysis of downstream kinases revealed that PTK/ZK reduced activation of PI3K/Akt kinase signaling
Lu et al., Eur J Immunol 1996 (Leukemia) : CD28 induced tyrosine phosphorylation and PI3-K activation was independent of p56lck protein tyrosine kinase ( PTK ) activity ( previously reported to be associated with CD28 ) and was insensitive to inhibition by the PTK inhibitor herbimycin A
Geltz et al., Blood 1998 : The protein tyrosine kinase inhibitor, erbstatin analog, partially inhibited p85 and p110 phosphorylation but did not appear to affect PI3K lipid kinase activity