Gene interactions and pathways from curated databases and text-mining

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PRKAR1A — PTK2

Pathways - manually collected, often from reviews:

  • BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) (modification, collaborate)

Text-mined interactions from Literome

Laxminarayana et al., J Immunol 1996 (Leukemia-Lymphoma, Adult T-Cell) : To confirm that PKA-I activation via the TCR/CD3 complex and IL-1R requires antecedent protein tyrosine kinase catalyzed phosphorylation of phospholipase C-gamma 1, we used wild-type and CD45-deficient ( mutant J45.01 ) Jurkat T cell lines
Fishman et al., Cancer Res 1997 (Fibrosarcoma...) : However, based on the discovery that activated PKA may inhibit ras mediated translocation of c-Raf-1 to the plasma membrane, it is generally accepted that the cross-talk between cAMP/PKA and p21ras mediated signal transduction pathways is unilateral, i.e., that the activation of PKA regulates growth factor receptor protein tyrosine kinase mediated signaling