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AKT2 — PTPN1

Text-mined interactions from Literome

Egawa et al., J Biol Chem 2001 (Carcinoma, Hepatocellular...) : In both cells, PTP1B overexpression blocked insulin stimulated tyrosine phosphorylation of the insulin receptor and IRS-1 by more than 70 % and resulted in a significant inhibition of the association between IRS-1 and the p85 subunit of phosphatidylinositol 3-kinase and Akt phosphorylation as well as mitogen activated protein kinase phosphorylation ... These effects were specific for insulin signaling, because platelet derived growth factor ( PDGF ) -stimulated PDGF receptor tyrosine phosphorylation and Akt phosphorylation were not inhibited by PTP1B overexpression
Shimizu et al., Endocrinology 2002 : Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen activated protein kinase in 3T3-L1 adipocytes
Vercauteren et al., Circulation 2006 (Cardiac Output, Low) : PTP1B inhibition stimulated early eNOS phosphorylation and increased phosphorylation of Akt
Venkatesan et al., FASEB J 2008 : Interestingly, resveratrol increased the activity of protein tyrosine phosphatase PTP1B , which dephosphorylates PDGF stimulated phosphorylation at tyrosine-751 and tyrosine-716 on PDGFR with concomitant reduction in Akt and Erk1/2 kinase activity
González-Rodríguez et al., Diabetes 2010 : The absence of PTP1B in the double-mutant mice restored hepatic IRS1 mediated phosphatidylinositol (PI) 3-kinase/Akt/Foxo1 signaling
Chen et al., Biochem Biophys Res Commun 2010 (Hyperglycemia...) : Here we report that BBR mimics insulin action by increasing glucose uptake ability by 3T3-L1 adipocytes and L6 myocytes in an insulin independent manner, inhibiting phosphatase activity of protein tyrosine phosphatase 1B (PTP1B) , and increasing phosphorylation of IR, IRS1 and Akt in 3T3-L1 adipocytes
Wang et al., Med Oncol 2012 (Disease Progression...) : Overexpression of PTP1B promoted the proliferation and in vivo tumorigenesis of MKN45 cells and also increased the phosphorylation levels of Akt , Erk1/2, and FAK and the activity of Src
Stull et al., Diabetes 2012 (Diabetes Mellitus, Type 2...) : PTP1B overexpression resulted in reduction of Akt phosphorylation in the control subjects