Gene interactions and pathways from curated databases and text-mining

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CASP9 — PTPN11

Text-mined interactions from Literome

Sol et al., J Virol 1999 (Parvoviridae Infections) : Since B19- and NS-1 induced apoptosis was inhibited by caspase 3, 6, and 8 inhibitors, and substantial caspase 3, 6, and 8 activities were induced by NS-1 expression, there may have been interactions between NS-1 and the apoptotic pathways of the death receptors tumor necrosis factor receptor 1 and Fas
Hideshima et al., Oncogene 2001 (MAP Kinase Signaling System...) : We demonstrate that Dex induced apoptosis in MM.1S cells is mediated by downstream activation of caspase-9 , with resultant caspase-3 cleavage ; and conversely, that IL-6 triggers activation of PI3-K and its association with SHP2 , inactivates caspase-9, and protects against Dex induced apoptosis