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PTPN2 — STAT1

Pathways - manually collected, often from reviews:

• NCI Pathway Database IFN-gamma pathway: TCPTP p45 (PTPN2) → STAT1 (dimer) complex (STAT1) (modification, activates)
  ten Hoeve et al., Mol Cell Biol 2002*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events mediated by TCPTP: TCPTP p45 (PTPN2) → STAT1 (dimer) complex (STAT1) (modification, activates)
  ten Hoeve et al., Mol Cell Biol 2002*, Wang et al., J Biol Chem 2006*, Krämer et al., Genes Dev 2009*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: PIAS1 (PIAS1) → STAT1 (dimer)/TCPTP p45 complex (STAT1-PTPN2) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) → TCPTP p45 (PTPN2) (modification, collaborate) Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) → STAT1 (dimer)/TCPTP p45 complex (STAT1-PTPN2) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: TCPTP p45 (PTPN2) → STAT1 (dimer) complex (STAT1) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: TCPTP p45 (PTPN2) → STAT1 (dimer)/TCPTP p45 complex (STAT1-PTPN2) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: STAT1 (dimer) complex (STAT1) → STAT1 (dimer)/TCPTP p45 complex (STAT1-PTPN2) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: STAT1 → PTPN2 (reaction) Simoncic et al., Curr Biol 2002, ten Hoeve et al., Mol Cell Biol 2002*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT1 — PTPN2 (physical association, affinity chromatography technology) Zhu et al., J Biol Chem 2002*
• IRef Biogrid Interaction: STAT1 — PTPN2 (physical association, affinity chromatography technology) Krämer et al., Genes Dev 2009*
• IRef Hprd Interaction: STAT1 — PTPN2 (in vitro) ten Hoeve et al., Mol Cell Biol 2002*, Sakamoto et al., J Biol Chem 2004*

Text-mined interactions from Literome

Shimizu et al., Exp Hematol 2003 : These results indicated that the loss of TC-PTP is involved in the IFN-alpha induced prolonged phosphorylation of Stat1 and in the higher sensitivity to IFN-alpha in KTR cells ... The loss of TC-PTP contributed to the IFN-alpha induced prolonged phosphorylation of Stat1 and the higher sensitivity to IFN-alpha in KTR cells
Nishiyama-Fujita et al., Leuk Res 2013 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Suppression of TC-PTP induced activation of STAT5, leading to imatinib resistance, while prolonged phosphorylation of STAT1 was induced by IFN-a, triggering cell death in KT-1 cells