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FYN — PTPRC

Pathways - manually collected, often from reviews:

• BioCarta t cell receptor signaling pathway: CD45 (PTPRC) → FYN (modification, activates)
• KEGG T cell receptor signaling pathway: PTPRC → FYN (protein-protein, dephosphorylation)
• WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection: PTPRC → FYN (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Ophid Interaction: FYN — PTPRC (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Cahir McFarland et al., J Biol Chem 1995 : CD45 activates the Src family protein-tyrosine kinases, p56lck and p59fyn , by dephosphorylating a negative regulatory tyrosine in the carboxyl terminus
Biffen et al., Eur J Immunol 1993 (Leukemia-Lymphoma, Adult T-Cell) : Selective coupling of the T cell antigen receptor to phosphoinositide derived diacylglycerol production in HPB-ALL T cells correlates with CD45 regulated p59fyn activity