Gene interactions and pathways from curated databases and text-mining

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PTTG2 — TP53

Text-mined interactions from Literome

Yu et al., Brain Pathol 2001 (Adenoma...) : PTTG expression activates p53 and causes p53 dependent and -independent apoptosis
Hamid et al., Molecular cancer 2004 (Breast Neoplasms...) : PTTG/securin activates expression of p53 and modulates its function ... Our results indicate that overexpression of PTTG regulates the expression of the p53 gene at both the transcriptional and translational levels and that this ability of PTTG to activate the expression of p53 gene is dependent upon the p53 status of the cell ... Deletion analysis of the p53 gene promoter revealed that only a small region of the p53 gene promoter is required for its activation by PTTG and further indicated that the activation of p53 gene by PTTG is an indirect effect that is mediated through the regulation of the expression of c-myc, which then interacts with the p53 gene promoter ... Overexpression of PTTG activates the expression of p53 and modulates its function, with this action of PTTG being mediated through the regulation of c-myc expression ... PTTG also up-regulates the activity of the bax promoter and increases the expression of bax through modulation of p53 expression