Gene interactions and pathways from curated databases and text-mining

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ITGAV — PVRL3

Pathways - manually collected, often from reviews:

  • NCI Pathway Database Nectin adhesion pathway: nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin complex (PVRL1-MLLT4-PVRL3) → alphav/beta3 Integrin/Talin complex (TLN1-ITGAV-ITGB3) (modification, activates)
    Sakamoto et al., J Biol Chem 2006
    Evidence: mutant phenotype, assay