Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — RAB5A

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Chen et al., EMBO Rep 2001 : We conclude that wortmannin alters intracellular trafficking of EGFR by activating Rab5 rather than by inhibiting PI3K
Vieira et al., Mol Cell Biol 2003 : Moreover, in the presence of PI3K inhibitors Rab5 was found to be active, as deduced from measurements of early endosome antigen 1 binding and by photobleaching recovery determinations
Maganto-Garcia et al., Traffic 2008 (Trypanosomiasis) : Assays carried out using a selective PI3K inhibitor ( LY294002 ) showed that the PI3K activation is essential for Rab5 activation by T. cruzi infection and for the entrance and intracellular replication of T. cruzi in macrophages
Runyan et al., J Biol Chem 2012 : As inhibiting PI3K can activate the endosomal fusion-regulatory small GTPase Rab5 , we expressed GTPase-deficient Rab5 and observed endosomal enlargement and reduced SARA protein expression, similar to that seen with PI3K inhibition
Simonsen et al., Nature 1998 : The association of EEA1 with the endosomal membrane requires Rab5-GTP and PI(3)K activity, and excess Rab5-GTP stabilizes the membrane association of EEA1 even when PI(3)K is inhibited