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PIK3R1 — RAB5A
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chen et al., EMBO Rep 2001
:
We conclude that wortmannin alters intracellular trafficking of EGFR by activating
Rab5 rather than by
inhibiting PI3K
Vieira et al., Mol Cell Biol 2003
:
Moreover, in the
presence of
PI3K inhibitors
Rab5 was found to be active, as deduced from measurements of early endosome antigen 1 binding and by photobleaching recovery determinations
Maganto-Garcia et al., Traffic 2008
(Trypanosomiasis) :
Assays carried out using a selective PI3K inhibitor ( LY294002 ) showed that the
PI3K activation is
essential for
Rab5 activation by T. cruzi infection and for the entrance and intracellular replication of T. cruzi in macrophages
Runyan et al., J Biol Chem 2012
:
As inhibiting
PI3K can
activate the endosomal fusion-regulatory small GTPase
Rab5 , we expressed GTPase-deficient Rab5 and observed endosomal enlargement and reduced SARA protein expression, similar to that seen with PI3K inhibition
Simonsen et al., Nature 1998
:
The association of EEA1 with the endosomal membrane requires Rab5-GTP and
PI(3)K activity, and excess
Rab5-GTP stabilizes the membrane association of EEA1 even when PI(3)K is inhibited