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PRL — RAC1

Text-mined interactions from Literome

Syed et al., Endocrine 2003 : Functional analysis revealed that overexpression of CypA inhibited PRL induced Rac activation, while simultaneously prolonging Jak2 phosphorylation
Miller et al., Oncogene 2007 (Breast Neoplasms...) : In contrast, downregulation of Nek3 expression by small interfering RNA ( siRNA ) attenuated PRL mediated cytoskeletal reorganization, activation of GTPase Rac1 , cell migration and invasion of T47D cells
Lee et al., Cancer Res 2007 : We next showed that 16k PRL reduced the activation of Rac1 in a concentration dependent manner ... Furthermore, 16k PRL inhibition of Rac1 is mediated through the suppression of T lymphoma invasion and metastasis 1 ( Tiam1 ) and its upstream activator Ras in a phosphoinositide-3-kinase independent manner