Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — RAC2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Nosaka et al., Biochem Biophys Res Commun 2001 (Fibrosarcoma) : The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation
Kanda et al., Biochem Biophys Res Commun 2003 : These results implicate CrkL in PI3K dependent activation of Rac by outside-in signaling from alpha4beta1 and suggest that adhesion through alpha4beta1 further activates cytokine receptor associated Jak2 to induce phosphorylation of these receptors
Welch et al., FEBS Lett 2003 (Second Messenger Systems) : Vice versa, Rac can also stimulate the activation of PI3K , although the mechanism for this is unclear
Alahari et al., Exp Cell Res 2003 : Furthermore, Nischarin does not affect Rac mediated JNK and PI3K activities
Sánchez-Martín et al., J Biol Chem 2004 : We have identified Vav, a guanine nucleotide exchange factor for Rac-1, and PI3K/Akt, as regulators of the activation and inactivation phases of the activity of Rac-1, respectively, in the context of LFA-1 signaling based on the following experimental evidence : ( i ) LFA-1 induced activation of Vav and PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1, ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation, ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity, and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited, respectively, Rac-1 activity
Felekkis et al., Mol Cancer Res 2005 (Breast Neoplasms) : Inhibition of PI3K with LY294002 or a dominant negative p85 construct blocked AND-34 mediated Rac and Akt activation ... Our studies suggest that AND-34 mediated PI3K activation induces Rac activation and anti-estrogen resistance in human breast cancer cell lines
Gouëffic et al., Cardiovasc Res 2006 : Hyaluronan induces vascular smooth muscle cell migration through RHAMM mediated PI3K dependent Rac activation ... HA-induced migration depends exclusively on RHAMM mediated PI3K dependent Rac activation
Vanni et al., Cell cycle (Georgetown, Tex.) 2006 : Inhibition of PI3K induces Rac activation and membrane ruffling in proto-Dbl expressing cells
Nielsen-Preiss et al., Endocrinology 2007 : In addition, PI3K inhibition in GnRH neuronal cells diminished Gas6 induced Rac activation
Nizhynska et al., Dev Neurobiol 2007 : Moreover, agrin induced activation of Rac and Cdc42 is impaired in the presence of PI3-K inhibitors
Samaga et al., PLoS Comput Biol 2009 (Liver Neoplasms) : Our results strongly suggest that the Rac/Cdc42 induced p38 and JNK cascades are independent of PI3K in both primary hepatocytes and HepG2
Beemiller et al., Mol Biol Cell 2010 : Inhibition of PI3K resulted in persistently active Cdc42 and Rac1, but not Rac2 , in stalled phagocytic cups
Deng et al., Dev Cell 2011 (Agammaglobulinemia...) : Noninvasive live imaging of Rac2 morphants or Rac2D57N zebrafish larvae demonstrates an essential role for Rac2 in regulating 3D motility and the polarization of F-actin dynamics and PI(3)K signaling in vivo