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PIK3R1 — RAF1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL2-mediated signaling events:
RAF1 (RAF1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype, other species
-
NCI Pathway Database SHP2 signaling:
RAF1 (RAF1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype
Text-mined interactions from Literome
Sutor et al., J Biol Chem 1999
:
Analysis of the upstream pathway leading to MEK activation revealed that inhibition of
PI3-K did not
block c-Raf activation, whereas MEK activation was effectively blocked under these conditions ... Because
c-Raf activation and MEK activation were inversely
affected by
PI3-K- and cAMP dependent pathways, we examined whether IL-3 activated the alternative Raf isoforms A-Raf and B-Raf
Guillemot et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a
p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves
PI3K and SHP-2
Nakayama et al., Biochem Biophys Res Commun 2003
(MAP Kinase Signaling System) :
We also demonstrated that
Raf1 is phosphorylated and
involved in the production of TNF-alpha and tyrosine phosphorylation of
PI3-K via ERK
Krepinsky et al., Cell Signal 2005
:
Although phosphatidylinositol-3-kinase (PI3-K) may mediate Raf-1 activation,
PI3-K inhibition with wortmannin or LY294002
had no effect on stretch induced
Raf-1 activation
Duca et al., Mol Pharmacol 2005
:
kappaE induced
Raf-1 phosphorylation and activation in a
PI3K dependent manner
Carpentier et al., Rev Neurol (Paris) 2005
(Brain Neoplasms...) :
High expression of the EGF receptor by tumor cells,
activation of the
PI3K/Akt and the
Ras/Raf pathways represent interesting targets for new selective drugs under development
Romano et al., Endocrinology 2006
:
Under the same conditions,
PI3K and Akt inhibition also both
increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein Rap1, which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Le Guilloux et al., Rev Neurol (Paris) 2008
(Brain Neoplasms...) :
High expression of the EGF receptor by tumor cells,
activation of the
PI3K/Akt and the
Ras/Raf pathways represent interesting targets for new selective drugs under development
Chang et al., Pharmacol Res 2009
:
Moreover, PKC-alpha and
PI3K signal might be
involved in YC-1 induced
Raf-1 activation
Yang et al., Eur J Pharmacol 2010
:
These results suggest that plumbagin activates NAD ( P ) H oxidase, Src, and PI3K, and that the activated
PI3K or PDK1 subsequently
stimulate Akt and
Ras-Raf-MEK1/2-ERK1/2 in 3T3-L1 cells
King et al., Mol Cell Biol 1997
:
Phosphatidylinositol 3-kinase is
required for integrin stimulated AKT and
Raf-1/mitogen activated protein kinase pathway activation