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NFKBIA — RAN
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Turpin et al., J Biol Chem 1999
:
Nuclear accumulation of
IkappaBalpha is
dependent on importins alpha and beta as well as the small
GTPase Ran , which are also responsible for the nuclear import mediated by basic nuclear localization sequences ( NLS )
Lee et al., J Biol Chem 2001
:
We now demonstrate that the N-terminal NES-like region, but not the C-terminal NES-like region, is required for
RanGTP dependent binding of
IkappaBalpha to CRM1 ... Taken together, our results demonstrate that the N-terminal NES-like sequence in IkappaBalpha is required for
RanGTP dependent binding of both free
IkappaBalpha and NFkappaB/Rel associated IkappaBalpha proteins to CRM1