Gene interactions and pathways from curated databases and text-mining

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NFKBIA — RAN

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Turpin et al., J Biol Chem 1999 : Nuclear accumulation of IkappaBalpha is dependent on importins alpha and beta as well as the small GTPase Ran , which are also responsible for the nuclear import mediated by basic nuclear localization sequences ( NLS )
Lee et al., J Biol Chem 2001 : We now demonstrate that the N-terminal NES-like region, but not the C-terminal NES-like region, is required for RanGTP dependent binding of IkappaBalpha to CRM1 ... Taken together, our results demonstrate that the N-terminal NES-like sequence in IkappaBalpha is required for RanGTP dependent binding of both free IkappaBalpha and NFkappaB/Rel associated IkappaBalpha proteins to CRM1