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BRCA1 — RBBP8

Pathways - manually collected, often from reviews:

• BioCarta atm signaling pathway: ATR/ATRIP/ATM complex (ATR-TREX1-ATM) → BRCA1/CTIP complex (BRCA1-RBBP8) (modification, activates)
  
• BioCarta atm signaling pathway: BRCA1/CTIP complex (BRCA1-RBBP8) → BRCA1 (modification, collaborate)
• BioCarta atm signaling pathway: BRCA1/CTIP complex (BRCA1-RBBP8) → CTIP (RBBP8) (modification, collaborate)
• BioCarta atm signaling pathway: BRCA1 → CTIP (RBBP8) (modification, collaborate)
• NCI Pathway Database BARD1 signaling events: ATM (ATM) → BRCA1/BARD1/CTIP/M/R/N Complex complex (MRE11A-RAD50-NBN-BRCA1-BARD1-RBBP8) (modification, activates)
  Greenberg et al., Genes Dev 2006
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: ATM (ATM) → BRCA1/BARD1/CTIP complex (BRCA1-BARD1-RBBP8) (modification, activates)
  Greenberg et al., Genes Dev 2006
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/CTIP/M/R/N Complex complex (MRE11A-RAD50-NBN-BRCA1-BARD1-RBBP8) → BRCA1/BARD1/CTIP complex (BRCA1-BARD1-RBBP8) (modification, collaborate)
  Greenberg et al., Genes Dev 2006
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/CTIP/M/R/N Complex complex (MRE11A-RAD50-NBN-BRCA1-BARD1-RBBP8) → M/R/N Complex complex (MRE11A-RAD50-NBN) (modification, collaborate)
  Greenberg et al., Genes Dev 2006
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/CTIP complex (BRCA1-BARD1-RBBP8) → M/R/N Complex complex (MRE11A-RAD50-NBN) (modification, collaborate)
  Greenberg et al., Genes Dev 2006
  Evidence: assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → CtBP/CtIP complex (RBBP8) (modification, collaborate) Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: CtBP/CtIP complex (RBBP8) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BARD1 signaling events: ATM (ATM) → BRCA1/BARD1/CTIP complex (BRCA1-BARD1-RBBP8) (modification, activates)
  Li et al., Nature 2000
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: CTIP (RBBP8) → BRCA1/BARD1/CTIP complex (BRCA1-BARD1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: CTIP (RBBP8) → BRCA1/BARD1 complex (BRCA1-BARD1) (modification, collaborate)
  Li et al., Nature 2000
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/CTIP complex (BRCA1-BARD1-RBBP8) → BRCA1/BARD1 complex (BRCA1-BARD1) (modification, collaborate)
  Li et al., Nature 2000
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/CTIP complex (BRCA1-BARD1-RBBP8) → CTIP (RBBP8) (modification, collaborate) Yu et al., J Biol Chem 2000*, Yu et al., J Biol Chem 1998*, Wong et al., Oncogene 1998*
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/CTIP complex (BRCA1-BARD1-RBBP8) → BRCA1/BARD1 complex (BRCA1-BARD1) (modification, collaborate)
  Yu et al., J Biol Chem 2000*, Yu et al., J Biol Chem 1998*, Wong et al., Oncogene 1998*
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: CTIP (RBBP8) → BRCA1/BARD1 complex (BRCA1-BARD1) (modification, collaborate)
  Yu et al., J Biol Chem 2000*, Yu et al., J Biol Chem 1998*, Wong et al., Oncogene 1998*
  Evidence: assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → CtBP/CtIP complex (RBBP8) (modification, collaborate) Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: CtBP/CtIP complex (RBBP8) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: RBBP8 — BRCA1 Wong et al., Oncogene 1998*
• IRef Bind Interaction: Complex of BRCA1-LMO4-LMO4-RBBP8 Sum et al., J Biol Chem 2002
• IRef Bind_translation Interaction: RBBP8 — BRCA1 (affinity chromatography technology) Wong et al., Oncogene 1998*
• IRef Bind_translation Interaction: RBBP8 — BRCA1 (two hybrid) Wong et al., Oncogene 1998*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Volcic et al., Nucleic Acids Res 2012*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Wang et al., Science 2007
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Furuta et al., Cancer Cell 2006*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, pull down) Drikos et al., Proteins 2009*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, unspecified method) Tischkowitz et al., Eur J Hum Genet 2008*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Li et al., Nature 2000
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Wu-Baer et al., Nature 2001*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Chen et al., J Biol Chem 2008*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, unspecified method) Rodriguez et al., J Biol Chem 2003
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, two hybrid) Li et al., J Biol Chem 1999*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, pull down) Li et al., J Biol Chem 1999*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Li et al., J Biol Chem 1999*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, two hybrid) Wong et al., Oncogene 1998*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, pull down) Wong et al., Oncogene 1998*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, two hybrid) Yu et al., J Biol Chem 1998*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Yu et al., J Biol Chem 1998*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Yu et al., J Biol Chem 2000*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, pull down) Yu et al., J Biol Chem 2000*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, two hybrid) Yu et al., J Biol Chem 2000*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Kim et al., Science 2007
• IRef Biogrid Interaction: RBBP8 — BRCA1 (direct interaction, enzymatic study) Yu et al., Genes Dev 2006*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (colocalization, imaging technique) Yu et al., Genes Dev 2006*
• IRef Biogrid Interaction: RBBP8 — BRCA1 (physical association, affinity chromatography technology) Wu-Baer et al., Mol Cell Biol 2010*
• MIPS CORUM LMO4-BRCA1-CTIP-LDB1 complex: LMO4-BRCA1-CTIP-LDB1 complex complex (BRCA1-LDB1-LMO4-RBBP8) Sum et al., J Biol Chem 2002
• MIPS CORUM BRCA1-LMO4-CTIP complex: BRCA1-LMO4-CTIP complex complex (BRCA1-LMO4-RBBP8) Sum et al., J Biol Chem 2002
• MIPS CORUM BRCA1-CTIP-ZBRK1 repressor complex: BRCA1-CTIP-ZBRK1 repressor complex complex (BRCA1-RBBP8-ZNF350) Furuta et al., Cancer Cell 2006*
• MIPS CORUM BRCA1 C complex: BRCA1 C complex complex (BARD1-BRCA1-RBBP8-UIMC1) Wang et al., Science 2007
• MIPS CORUM BRCA1-BARD1-BACH1-DNA damage complex II: BRCA1-BARD1-BACH1-DNA damage complex II complex (BACH1-BARD1-BRCA1-MRE11A-NBN-RAD50-RBBP8-TOPBP1) Greenberg et al., Genes Dev 2006
• MIPS CORUM BRCA1-CtIP-CtBP complex: BRCA1-CtIP-CtBP complex complex (BRCA1-CTBP1-RBBP8) Li et al., J Biol Chem 1999*
• IRef Corum Interaction: Complex of BRCA1-RBBP8-LDB1-LMO4 (association, anti bait coimmunoprecipitation) Sum et al., J Biol Chem 2002
• IRef Corum Interaction: Complex of BRCA1-RBBP8-LMO4 (association, anti tag coimmunoprecipitation) Sum et al., J Biol Chem 2002
• IRef Corum Interaction: Complex of RBBP8-CTBP1-BRCA1 (association, anti bait coimmunoprecipitation) Li et al., J Biol Chem 1999*
• IRef Corum Interaction: Complex of UIMC1-BRCA1-RBBP8-BARD1 (association, coimmunoprecipitation) Wang et al., Science 2007
• IRef Corum Interaction: Complex of BRCA1-ZNF350-RBBP8 (association, anti bait coimmunoprecipitation) Furuta et al., Cancer Cell 2006*
• IRef Corum Interaction: Complex of 17 proteins (association, cosedimentation through density gradient) Greenberg et al., Genes Dev 2006
• IRef Dip Interaction: Complex of BRCA1-PALB2-RBBP8-BRIP1 (anti bait coimmunoprecipitation) Sy et al., Proc Natl Acad Sci U S A 2009
• IRef Dip Interaction: Complex of BRIP1-PALB2-BRCA2-RBBP8-RAD51-RPA1-BRCA1 (physical association, molecular sieving) Sy et al., Proc Natl Acad Sci U S A 2009
• IRef Hprd Interaction: RBBP8 — BRCA1 (in vivo) Li et al., J Biol Chem 1999*, Yu et al., J Biol Chem 1998*, Wong et al., Oncogene 1998*
• IRef Hprd Interaction: RBBP8 — BRCA1 (in vitro) Li et al., J Biol Chem 1999*, Yu et al., J Biol Chem 1998*, Wong et al., Oncogene 1998*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Sum et al., J Biol Chem 2002
• IRef Hprd Interaction: Complex of BRCA1-BRCA1-RBBP8-LMO4-LMO4-BRCA1-RBBP8-LMO4-RBBP8 (in vivo) Sum et al., J Biol Chem 2002
• IRef Intact Interaction: Complex of FAM175A-BRCA1-RBBP8-UIMC1 (association, anti bait coimmunoprecipitation) Wang et al., Science 2007
• IRef Intact Interaction: Complex of BRIP1-UIMC1-RBBP8-BRCA1 (association, tandem affinity purification) Wang et al., Science 2007
• IRef Intact Interaction: RBBP8 — BRCA1 (physical association, pull down) Ye et al., J Cell Biol 2001*
• IRef Intact Interaction: RBBP8 — BRCA1 (physical association, anti bait coimmunoprecipitation) Wang et al., Science 2007
• IRef Intact Interaction: RBBP8 — BRCA1 (physical association, two hybrid) Wong et al., Oncogene 1998*
• IRef Intact Interaction: RBBP8 — BRCA1 (physical association, pull down) Wong et al., Oncogene 1998*
• IRef Intact Interaction: Complex of BRIP1-BRCA1-FAM175A-RBBP8-UIMC1 (association, anti bait coimmunoprecipitation) Wang et al., Science 2007
• IRef Ophid Interaction: RBBP8 — BRCA1 (aggregation, confirmational text mining) Wong et al., Oncogene 1998*
• IRef Ophid Interaction: RBBP8 — BRCA1 (aggregation, confirmational text mining) Li et al., J Biol Chem 1999*
• IRef Ophid Interaction: RBBP8 — BRCA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Sum et al., J Biol Chem 2002 (Breast Neoplasms) : Tumor associated mutations within the BRCT repeats that abolish interaction between BRCA1 and CtIP had no effect on the association of BRCA1 with LMO4
Foray et al., EMBO J 2003 : We show here that BRCA1 is required for ATM- and ATR dependent phosphorylation of p53, c-Jun, Nbs1 and Chk2 following exposure to ionizing or ultraviolet radiation, respectively, and is also required for ATM phosphorylation of CtIP
Delouis et al., BMC molecular biology 2005 : The stimulatory effect of two BRCA1 mutants, specifically in NT cells, implicates a tripartite BRCA1-CtIP-CtBP1 complex in the regulation of the K18 promoter