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CREB3 — RCAN1
Text-mined interactions from Literome
Kim et al., J Biol Chem 2011
(Down Syndrome) :
In this report, we found that the
regulator of calcineurin 1 (RCAN1) , which is overexpressed in the brain of patients with Down syndrome,
increased the phosphorylation of
CREB and cAMP response element mediated gene transcription in response to the activation of the intracellular cAMP pathway ... Furthermore, we found that the increased
activation of
CREB signaling by
RCAN1 depended on the ability of RCAN1 to inhibit calcineurin activity ... Our data provide the first evidence that
RCAN1 acts as an important regulatory component in the control of
CREB signaling
Kim et al., J Cell Biochem 2013
:
In contrast,
RCAN1 significantly
enhanced the activity of cAMP response element binding protein (
CREB ) ... In contrast,
RCAN1 significantly
enhanced the activity of cAMP response element binding protein (
CREB ) ... Furthermore,
RCAN1 induced the expression of the
CREB target gene, Bcl-2 ... Furthermore,
RCAN1 induced the expression of the
CREB target gene, Bcl-2