Kim et al., J Ethnopharmacol 2007
(Diabetes Mellitus, Experimental...) :
As the results, we found that KIOM-79 reduced hyperglycemia ( p < 0.01 ), ameliorated insulin resistance ( p < 0.001 ), urinary protein excretion ( p < 0.01 ) and creatinine clearance ( Ccr ) ( p < 0.001 ), and inhibited glomerular AGE formation ( p < 0.001 ) in diabetic GK rats
Isoda et al., Atherosclerosis 2008
:
These data show that AGE-LDL can increase CCR2 expression in macrophages and stimulate the chemotactic response elicited by MCP-1