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Yamaguchi et al., Mol Cell Biochem 1999
:
The presence of
regucalcin ( 10 ( -9 ) to 10 ( -7 ) M ) in the enzyme reaction mixture
caused a significant decrease in
Ca2+-ATPase activity in the brain microsomes of young rats ( 5 weeks old ) ... The present study demonstrates that
regucalcin is expressed in the brain, and that it can uniquely
inhibit Ca2+-ATPase activity in the brain microsomes of rats ... The findings suggest that
regucalcin plays a role in the regulation of microsomal
Ca2+-ATPase activity in rat brain tissues
Yamaguchi et al., J Cell Biochem 2002
(Body Weight) :
Regucalcin inhibited protein phosphatase activity in rat kidney cortex cytosol and
activated Ca2+-ATPase activity in rat heart muscle microsomes
Akhter et al., Int J Mol Med 2006
:
Regucalcin increases
Ca2+-ATPase activity in the heart mitochondria of normal and regucalcin transgenic rats ... The
role of
regucalcin , a regulatory protein in intracellular signaling system, in the regulation of
Ca2+-ATPase activity in rat heart mitochondria was investigated ...
Regucalcin ( 10 ( -9 ) M ) did not have a significant
effect on
Ca2+-ATPase activity in the presence of digitonin ( 10 ( -3 ) or 10 ( -2 ) % ), which is a solubilization effect on membranous lipids
Yamaguchi et al., Chem Pharm Bull (Tokyo) 1990
:
Regucalcin induced
Ca2+ release from rat liver microsomes : the effect is inhibited by heparin ... The effect of heparin on the calcium binding protein
regucalcin stimulated
Ca2+ release from rat liver microsomes was investigated ... These results suggest that
regucalcin affects
45Ca2+ release involved in Ins ( 1,4,5 ) P3 action in rat liver microsomes
Yamaguchi et al., Biochem Med Metab Biol 1990
:
Regucalcin , a calcium binding protein isolated from rat liver cytosol,
inhibited Ca2 ( + ) - and phospholipid dependent protein kinase ( protein kinase C ) activity in hepatic cytosol ... This inhibitory effect of regucalcin may be due to the
regucalcin induced
Ca2+ binding and/or the direct binding of regucalcin to protein kinase C
Yamaguchi et al., Chem Pharm Bull (Tokyo) 1989
:
The
effect of
regucalcin , a calcium binding protein isolated from rat liver cytosol, on
Ca2+-adenosine triphosphatase (ATPase) activity in hepatic microsomes was investigated ...
Regucalcin ( 2.0 microM ) did not
enhance the effect of V5+ and Cd2+ on
Ca2+-ATPase activity ... The present finding, that
regucalcin activates hepatic microsomal
Ca2+-ATPase , suggests a cell physiological role of regucalcin as an activator in the microsomal Ca2+-pump activity
Yamaguchi et al., Chem Pharm Bull (Tokyo) 1989
:
The presence of oxalate ( 3 mM ) completely blocked the
effect of
regucalcin on
45Ca2+ release from the microsomes
Takahashi et al., Mol Cell Biochem 1993
:
Moreover,
regucalcin ( 0.5 microM )
increased significantly the enzyme activity in the absence of
Ca2+
Kurota et al., Mol Cell Biochem 1997
:
Regucalcin increases
Ca2+-ATPase activity and ATP dependent calcium uptake in the microsomes of rat kidney cortex ... The presence of
regucalcin ( 10 [ -8 ] to 10 [ -6 ] M ) in the reaction mixture
caused a significant increase in
Ca2+-ATPase activity and ATP dependent 45Ca2+ uptake in the microsomes ...
Regucalcin ( 10 [ -7 ] M )
increased Ca2+-ATPase activity independently of increasing concentrations of CaCl2 ... The
effect of
regucalcin ( 10 [ -7 ] M ) on
Ca2+ATPase activity and 45Ca2+ uptake was weakened in the presence of DcAMP or IP3
Kurota et al., Biol Pharm Bull 1998
:
This inhibitory effect may be partly due to the
regucalcin induced
Ca2+ binding
Omura et al., J Cell Biochem 1998
:
The regulatory effect of regucalcin on
Ca2+/calmodulin dependent phosphatase activity and the binding of
regucalcin to calmodulin was investigated